Articles
Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?
Dialogues in clinical neuroscience – December 01, 2025
Summary
With dementia rates rising globally, Alzheimer's disease presents a complex healthcare challenge, especially due to its comorbidities. Recent findings suggest that psychedelic therapy could enhance neuroplasticity and emotional well-being, offering innovative solutions to improve comprehensive care for those affected by Alzheimer's and its associated conditions.
Abstract
The increasing prevalence of dementia within an ageing global population, combined with prolonged life expectancy, accentuates Alzheimer's disease ...
Harmine derivative H-2-168 induces the death of Echinococcus granulosus by regulating mitochondrial fusion and fission.
Pharmaceutical biology – December 01, 2025
Summary
A promising compound, H-2-168, effectively targets Echinococcus granulosus, the parasite responsible for cystic echinococcosis. By disrupting mitochondrial balance through Drp1 regulation, it significantly reduces the parasite's viability. This innovative approach highlights a potential new strategy in combating this challenging infection.
Abstract
H-2-168 has pharmacological effects similar to those of harmine, with less toxicity. The health of cells and organisms depends on a delicate balanc...
Association of e-cigarette use, psychological distress, and substance use: Insights from the All of Us Research Program.
Addictive behaviors – July 01, 2025
Summary
E-cigarette users often experience higher levels of psychological distress and substance use. An analysis of over 68,000 adults revealed that current users had significantly more depressive symptoms and substance use compared to non-users. This highlights the need for awareness and targeted interventions to support mental well-being among e-cigarette users.
Abstract
Understanding the social context of e-cigarette use in the United States (U.S.) remains a high priority. In this cross-sectional study, we included...
Side effects of microdosing lysergic acid diethylamide and psilocybin: A systematic review of potential physiological and psychiatric outcomes.
Neuropharmacology – June 15, 2025
Summary
Microdosing psychedelics like LSD and psilocybin is gaining popularity for enhancing mood and reducing anxiety. A systematic review examined the side effects of this practice, finding that most were mild, short-lived, and dose-dependent. Common issues included increased blood pressure and temporary cognitive impairment, highlighting the need for clearer reporting in future studies.
Abstract
Psychedelics are gaining renewed attention, especially through the practice of microdosing, where low doses are taken regularly. Microdosing lyserg...
Thermal transformation of CBD, CBDA, and Δ9-THC during e-cigarette vaping: Identification of conversion products by GC-MS.
Journal of chromatography. A – May 24, 2025
Summary
Vaping cannabinoids can transform them into various psychoactive products, raising intriguing questions about their effects. Using a lab-built vaping device and GC-MS analysis, researchers explored how increasing coil power alters the thermal transformation of CBDA, CBD, and Δ9-THC. They found that higher temperatures produced several interesting compounds, including Δ8-THC isomers and HHC derivatives, while potentially harmful CBDQ peaked at lower temperatures. This study sheds light on cannabinoid behavior during vaping, offering insights for risk assessment.
Abstract
The use of electronic cigarettes (e-cigarettes) has gained popularity worldwide for reducing the unpleasant odors and flavors of smoking marijuana....
Chromatographic interferences potentially inflating the levels of Δ9-THC in Cannabis Sativa plant samples and possible solutions.
Journal of chromatography. A – May 10, 2025
Summary
A recent study reveals that certain cannabinoids can interfere with liquid chromatography measurements, potentially inflating Δ9-tetrahydrocannabinol (Δ9-THC) levels in hemp samples, misclassifying them as marijuana. By refining analytical methods, researchers have effectively addressed these interferences, ensuring accurate identification of Cannabis sativa plants.
Abstract
Researchers in the Chemical Sciences Division (CSD) at the National Institute of Standards and Technology (NIST) have been evaluating existing and ...
CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure.
Behavioural brain research – May 08, 2025
Summary
Maternal inflammation during pregnancy can impact cognitive behavior in offspring, especially with rising prenatal cannabis exposure. This study reveals that the CB1 receptor plays a key role in impairments from cannabis use, while the CB2 receptor influences outcomes from maternal immune activation. Interestingly, combined exposure may protect against these effects.
Abstract
Maternal immune activation (MIA) commonly arises in response to an infection during pregnancy. MIA elevates cytokine levels, triggering an inflamma...
The Earliest Descriptions and Treatments for Migraine: From the Dawn of Civilization to Galen (P5-12.004).
Neurology – April 08, 2025
Summary
Ancient civilizations approached migraine treatment with a blend of physical, spiritual, and ritualistic methods. This review highlights diverse therapies from Mesopotamia to China, revealing how early practices, like herbal infusions and acupuncture, laid foundations for modern pain management. These historical insights enrich our understanding of headache care today.
Abstract
This review aims to explore and compare cross-cultural ancient headache treatments and their potential equivalent in current medical therapeutic ap...
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Unreal? A Behavioral, Physiological, and Computational Model of the Sense of Reality
bioRxiv – April 07, 2025
Summary
Did you know our minds constantly assess the reality of our perceptions? A recent study explored this by using virtual reality to simulate visual hallucinations. Researchers found that our sense of reality varies with the intensity of these experiences, revealing distinct physiological responses. This suggests our brain compares sensory input to an internal model to determine what feels real.
Abstract
An intriguing aspect of the human mind is our knowledge that our perceptions may be false. Our frequent exposure to non-veridical perceptions such ...
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Obsessive-compulsive symptoms and traits in patients with burning mouth syndrome: a cross-sectional multicentric analysis.
Clinical oral investigations – April 05, 2025
Summary
In patients with Burning Mouth Syndrome, nearly 42% exhibit significant obsessive-compulsive symptoms, while 37% show traits of Obsessive-Compulsive Personality Disorder. Utilizing tools like OCI-R and CPAS can help clinicians tailor treatments, enhancing management strategies for these overlapping conditions.
Abstract
This study investigates the frequency and characteristics of obsessive-compulsive (OC) symptoms and Obsessive-Compulsive Personality Disorder (OCPD...
Global landscape and hotspot analysis of meditation research in cancer: a bibliometric study.
Journal of cancer survivorship : research and practice – April 05, 2025
Summary
Meditation is increasingly recognized for enhancing the well-being of cancer patients. A bibliometric analysis of 825 articles reveals a growing scholarly interest in its benefits, particularly in improving quality of life and reducing psychological stress. Key research frontiers include mindfulness therapy and innovative virtual approaches, highlighting meditation's promising role in cancer care.
Abstract
Meditation is well known for its positive effects on recovery and quality of life enhancement among cancer patients. Meditation as an adjuvant ther...
Single-cell sequencing exposes mast cell-derived CD52's anti-tumor action in breast cancer through the IL-6/JAK/STAT3 axis.
International journal of biological macromolecules – April 05, 2025
Summary
Recent findings highlight the role of CD52 from mast cells in combating triple-negative breast cancer (TNBC). Using RNA sequencing, researchers discovered that CD52 inhibits tumor growth by targeting the IL-6/JAK/STAT3 pathway. This insight opens doors for innovative immunotherapy approaches, enhancing treatment prospects for TNBC patients.
Abstract
The aggressive nature and rapid progression of triple-negative breast cancer (TNBC), coupled with a high likelihood of recurrence and mortality, un...
Comprehensive 3D imaging of whole zebrafish using a water-based clearing reagent for hard tissues
bioRxiv – April 04, 2025
Summary
Zebrafish are key to understanding development, but their dense tissues often hinder deep imaging. A new technique using the LUCID clearing reagent allows for complete 3D imaging of these fish, preserving details and fluorescent signals in hard tissues like bone and cartilage. This advancement opens new avenues for studying zebrafish anatomy.
Abstract
Zebrafish (Danio rerio) is a valuable model organism for studying developmental processes due to its external development and the optical clarity o...
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Mind-body therapies and their interplay with the immune system in children and adolescents: a protocol for a systematic review and meta-analysis.
Systematic reviews – April 04, 2025
Summary
Chronic inflammation poses serious health risks for children and adolescents, but mind-body therapies like yoga and meditation may help. This systematic review and meta-analysis will evaluate how these complementary medicine approaches impact the immune system in young people, aiming to enhance their health and well-being.
Abstract
Chronic inflammation is a critical public health concern that, in children and adolescents, increases the long-term risk of a variety of different ...
Psychedelics as pharmacotherapeutics for substance use disorders: a scoping review on clinical trials and perspectives on underlying neurobiology
medRxiv – April 04, 2025
Summary
Psychedelics are emerging as promising treatments for substance use disorders, showing potential to reshape recovery approaches. This review highlights clinical trials using these substances and suggests they may restore dopamine balance, reducing cravings and supporting abstinence. The findings point to a hopeful future for therapeutic applications.
Abstract
Psychedelics have garnered great attention in recent years as treatments for major depressive disorder and treatment-resistant depression due to th...
Effects of transcranial direct current stimulation (tDCS) at different cortical targets on cognition in obsessive-compulsive disorder (OCD): an exploratory analysis.
International clinical psychopharmacology – April 04, 2025
Summary
Transcranial direct current stimulation (tDCS) shows potential in enhancing cognitive flexibility for those with obsessive-compulsive disorder (OCD). In a study involving 19 adults, tDCS targeting specific brain areas significantly improved cognitive flexibility, while sham treatment did not. This suggests tDCS could be a promising tool in OCD therapy.
Abstract
Transcranial direct current stimulation (tDCS) holds promise as a treatment for obsessive-compulsive disorder (OCD). Patients with OCD show impairm...
Clinical knowledge, experiences, and perceptions of yoga providers in arthritis treatment: a UK-based qualitative study.
Rheumatology international – April 04, 2025
Summary
Yoga providers in the UK are increasingly recognized for their role in supporting individuals with arthritis. Through interviews, they shared insights on delivering gentle yoga as a mind-body therapy, emphasizing the importance of tailored practices and empathy. They believe that with better promotion and training, yoga can significantly enhance arthritis treatment.
Abstract
This study explored yoga providers' clinical knowledge of arthritis, experiences of delivering yoga to people with arthritis, their perceived role ...
Addressing blinding in classic psychedelic studies with innovative active placebos.
The international journal of neuropsychopharmacology – April 04, 2025
Summary
Classic psychedelics show great potential for treating neuropsychiatric disorders, but weak blinding in studies can skew results. This review highlights the need for innovative active placebos that mimic drug effects without therapeutic benefits. By improving control conditions, researchers can better assess the true efficacy and safety of psychedelics.
Abstract
Classic psychedelics show promise as a treatment for various neuropsychiatric disorders. However, weak blinding integrity in trials has been argued...
A pilot intervention to reduce burnout and enhance resilience through transcendental meditation among Georgetown University medical students.
BMC medical education – April 03, 2025
Summary
Amid rising burnout and emotional exhaustion among medical students, a study found that Transcendental Meditation (TM) significantly reduces anxiety and enhances resilience. Over three months, participants showed marked improvements in well-being, with 85% adherence to practice. TM proves to be an effective tool for managing academic stress and fostering mental health.
Abstract
Rates of burnout, depression, and anxiety among healthcare workers are at historically high levels and have remained high in the aftermath of the C...
Exploring psilocybin's role in mental health and palliative medicine: a path to improved well-being.
Expert opinion on emerging drugs – April 03, 2025
Summary
Recent findings highlight psilocybin, a psychedelic compound, as a promising treatment for depression and in palliative care. Clinical trials reveal its potential to alleviate symptoms, especially in treatment-resistant cases, offering hope for improved well-being. This innovative approach may transform mental health strategies and end-of-life care.
Abstract
Although long known for their psychoactive effects, psychedelic drugs have only recently been investigated for medicinal use. Psilocybin has attrac...
Escape Game to Promote Students' Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention.
JMIR research protocols – April 02, 2025
Summary
The COVID-19 pandemic has significantly affected students' mental health, prompting innovative solutions like the EscapeCovid Game. This cocreated digital escape game aims to enhance mental health outcomes through engaging gameplay. A pilot randomized controlled trial with 500 students showed promising results, improving mental health literacy and coping strategies.
Abstract
The COVID-19 pandemic and the protracted lockdowns have heavily impacted university students' mental health. Digital Escape Games represent a good ...
Effect of Anapanasati Meditation on Thought Patterns and Subjective Well-being Among Orphan Adolescents.
Annals of neurosciences – April 02, 2025
Summary
Practicing Anapanasati meditation for just three months significantly improved emotional regulation and well-being among orphan adolescents. Participants reported enhanced self-awareness, better peer communication, and a more optimistic outlook on life. This ancient technique proved effective in fostering positive emotional changes, highlighting its transformative potential.
Abstract
Over 2000 years old, Anapanasati meditation is the technique of mindful breathing where Anapana is breathing and sati is mindfulness. Anapanasati m...
Psilocybin's lasting action requires pyramidal cell types and 5-HT2A receptors.
Nature – April 02, 2025
Summary
A single dose of psilocybin can enhance neural connections in the brain, potentially offering therapeutic benefits for mental health. This study reveals that specific pyramidal cells in the medial frontal cortex are crucial for psilocybin's effects, with 5-HT2A receptors playing a vital role in promoting positive behavioral changes.
Abstract
Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses1-4. At the cellular level, psychedelics induce st...
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Neuroplasticity and Psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.
Neuroscience and biobehavioral reviews – April 02, 2025
Summary
Psychedelics may reshape our understanding of brain health, showing promise in treating mood disorders by enhancing functional and structural neuroplasticity. Research indicates these compounds boost the nervous system's adaptability, fostering long-term changes that could revolutionize therapeutic approaches. Exciting advancements in imaging techniques are paving the way for deeper insights into their potential.
Abstract
Neuroplasticity, the ability of the nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment t...
Effects of Virtual Reality Meditation on Sleep and Delirium in ICU Patients: A Randomized Controlled Trial.
Computers, informatics, nursing : CIN – April 02, 2025
Summary
Virtual reality meditation can enhance sleep quality for ICU patients, offering a calming escape amid stress. In a trial with 96 participants, those using VR meditation reported better sleep than those receiving standard care, though objective sleep metrics showed no significant difference. Delirium rates were similar across both groups, highlighting the potential of innovative approaches in critical care.
Abstract
The purpose of this study was to evaluate the effectiveness of virtual reality meditation compared with standard care on sleep quality and delirium...
Neurobehavioural Correlates of Breath Meditation in Novice Adolescents: Insights from Anapanasati-based Paradigm.
Annals of neurosciences – April 02, 2025
Summary
Breath meditation can significantly enhance relaxation and mindfulness in adolescents, as shown by a study using electroencephalography (EEG) to measure brain activity during a structured breath-awareness intervention. Increased alpha oscillation indicated relaxation, while positive associations between breath counting and cognitive processing emerged. Notably, mindfulness correlated with enhanced frontal brain activity, suggesting that inward focus may reduce outward social awareness. Gender differences were observed, with females displaying greater mindfulness and brain activity. This highlights the potential of breath meditation in promoting psychological well-being among adolescents.
Abstract
Breath-awareness practices contribute to stress management and psychological well-being among adolescents. However, their neurobehavioural effects ...
Barrier effects on the kinetics of cohesin-mediated loop extrusion.
Biophysical journal – April 02, 2025
Summary
Cohesin plays a vital role in organizing chromosomes by forming loops, but its process can be influenced by other proteins. This study reveals that physical barriers can actually speed up loop formation, especially when close to cohesin loading sites. In contrast, chemical barriers slow it down. These findings enhance our understanding of gene regulation and chromatin organization.
Abstract
Chromosome organization mediated by structural maintenance of chromosome complexes is crucial in many organisms. Cohesin extrudes chromatin into lo...
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[Promoting Self-Care and Resilience in High-Stress Nursing Workplaces].
Hu li za zhi The journal of nursing – April 01, 2025
Summary
Nurses face significant burnout, with many under 25 experiencing it at alarming rates. This study highlights effective self-care and resilience strategies, like mindfulness and virtual reality meditation, to combat stress in high-pressure environments. Such interventions promote well-being, enhance job satisfaction, and improve patient care outcomes.
Abstract
Staffing shortages and excessive workloads are issues faced by nurses worldwide. In the United States, 62% of nurses experience burnout, with burno...
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Psychedelics, spirituality, and existential distress in patients at the end of life.
Cleveland Clinic journal of medicine – April 01, 2025
Summary
Psychedelics may offer profound relief for patients facing existential distress at the end of life. Recent insights suggest these substances can enhance spirituality and alleviate deep-seated fears associated with dying. This exploration encourages a broader conversation about their potential therapeutic use in end-of-life care.
Abstract
Psychedelic-assisted therapy clinical trials conducted over the past decade have prompted increased interest in the use of psychedelics to treat no...
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Psilocybin Dispensaries and Online Health Claims in Canada.
JAMA network open – April 01, 2025
Summary
In May 2024, Canada had 57 psilocybin dispensaries, primarily in Ontario and British Columbia, revealing a growing market despite legal restrictions. While many stores claimed mental health benefits, they often overlooked crucial safety warnings. This highlights the need for better regulations to ensure public safety amid rising interest in psilocybin.
Abstract
There is growing societal interest in and use of psilocybin. While psilocybin in Canada is illegal outside of clinical trials, there have been anec...