4 Articles by Robin Carhart-Harris
Neuroplasticity and Psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.
Neuroscience and biobehavioral reviews – April 02, 2025
Summary
Psychedelics may reshape our understanding of brain health, showing promise in treating mood disorders by enhancing functional and structural neuroplasticity. Research indicates these compounds boost the nervous system's adaptability, fostering long-term changes that could revolutionize therapeutic approaches. Exciting advancements in imaging techniques are paving the way for deeper insights into their potential.
Abstract
Neuroplasticity, the ability of the nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment t...
Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).
Communications biology – March 11, 2025
Summary
Psychedelics can rapidly alter brain dynamics, creating heightened states of awareness. In a study with 15 participants, researchers simulated brain activity during DMT exposure, revealing a temporary surge in reactivity, especially in areas tied to perception and cognition. This insight enhances our understanding of how brief psychedelic experiences can leave lasting impressions.
Abstract
The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects...
Tags
Psilocybin for disorders of consciousness: A case-report study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology – March 08, 2025
Summary
In a groundbreaking case, psilocybin was administered to a patient in a minimally conscious state due to severe brain injury. While traditional behavioral assessments showed no improvement, the treatment sparked new spontaneous behaviors and enhanced brain complexity. This intriguing finding opens avenues for psychedelics as a potential therapy for disorders of consciousness.
Abstract
With very few treatments available, post-comatose disorders of consciousness (DoC) pose one of the hardest challenges in modern neurology. Followin...
LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics.
PLoS Computational Biology – February 23, 2023
Summary
Psychedelics like LSD may enhance brain complexity by pushing it into a more disordered state. Analyzing fMRI data, researchers found that LSD increases the Ising temperature of brain dynamics, indicating greater disorder and reduced interhemispheric connectivity. This shift suggests a unique brain state that fosters creativity and insight.
Abstract
A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organi...