2 Articles by Gustavo Deco

Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).

Communications biology – March 11, 2025

Summary

Psychedelics can rapidly alter brain dynamics, creating heightened states of awareness. In a study with 15 participants, researchers simulated brain activity during DMT exposure, revealing a temporary surge in reactivity, especially in areas tied to perception and cognition. This insight enhances our understanding of how brief psychedelic experiences can leave lasting impressions.

Abstract

The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects...

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics.

PLoS Computational Biology – February 23, 2023

Summary

Psychedelics like LSD may enhance brain complexity by pushing it into a more disordered state. Analyzing fMRI data, researchers found that LSD increases the Ising temperature of brain dynamics, indicating greater disorder and reduced interhemispheric connectivity. This shift suggests a unique brain state that fosters creativity and insight.

Abstract

A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organi...