1 Article by Rachel Hahn
CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice.
Pharmacological research – April 01, 2025
Summary
Synthetic cannabinoids can lead to acute respiratory failure, a risk often overlooked with THC, the main compound in cannabis. This study revealed that both THC and another cannabinoid significantly reduced breathing in mice by acting on brain regions essential for respiration. Notably, they also interacted with opioid pathways, highlighting potential overdose risks.
Abstract
Recreational use of synthetic cannabinoid agonists (i.e., "spice compounds") that target the cannabinoid type 1 receptor (CB1) can cause acute resp...