5 Articles by Otto Simonsson
Addressing blinding in classic psychedelic studies with innovative active placebos.
The international journal of neuropsychopharmacology – April 04, 2025
Summary
Classic psychedelics show great potential for treating neuropsychiatric disorders, but weak blinding in studies can skew results. This review highlights the need for innovative active placebos that mimic drug effects without therapeutic benefits. By improving control conditions, researchers can better assess the true efficacy and safety of psychedelics.
Abstract
Classic psychedelics show promise as a treatment for various neuropsychiatric disorders. However, weak blinding integrity in trials has been argued...
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
Journal of psychiatric research – April 01, 2025
Summary
Psychedelic experiences can enhance mindfulness and self-compassion, promoting healthier meditation practices. In a study of over 13,000 participants, those who used psychedelics reported increased compassion meditation, especially if they were new to both psychedelics and meditation. This suggests positive associations that may reduce adverse experiences and harm.
Abstract
Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitu...
Longitudinal associations of naturalistic psychedelic use with psychotic and manic symptoms.
Psychological medicine – March 31, 2025
Summary
Engaging with psychedelics outside clinical settings may carry risks, especially for those with a history of schizophrenia or bipolar disorder. A study found that illegal psychedelic use linked to increased psychotic and manic symptoms, depending on frequency and personal experiences. Insights gained during these experiences could mitigate some risks.
Abstract
Findings from contemporary clinical trials suggest that psychedelics are generally safe and may be effective in the treatment of various psychiatri...
Lifetime classic psychedelic use and headaches: A cross-sectional study.
Journal of psychopharmacology (Oxford, England) – March 12, 2025
Summary
Individuals who have used classic psychedelics like LSD and psilocybin may experience fewer frequent headaches, including migraines and cluster headaches. An analysis of over 11,000 participants revealed a 25% reduction in the likelihood of experiencing severe headaches among psychedelic users. This suggests exciting potential for new treatment options.
Abstract
Migraine and cluster headache are two primary headache disorders for which conventional treatments are limited. Classic psychedelic substances such...
On Minimizing Risk and Harm in the Use of Psychedelics.
Psychiatric research and clinical practice – January 01, 2025
Summary
A group of 30 psychedelic researchers highlights the need for a robust safety framework in psychedelic use. They pinpoint gaps in understanding potential harms and effective treatments, advocating for enhanced support systems like peer groups and affordable therapy. By proposing that investors allocate 1% of their funds to safety initiatives, they aim to foster a safer environment for exploring these promising substances.
Abstract
This article outlines recommendations from 30 psychedelic researchers on how to create a better psychedelic safety net. A survey of 30 psychedelic ...