1 Article by Charles D Nichols
Preadministration of Lorazepam Reduces Efficacy and Longevity of Antidepressant-Like Effect from a Psychedelic.
Psychedelic medicine (New Rochelle, N.Y.) – March 01, 2024
Summary
Psychedelics like psilocybin show promise in treating depression, but their effectiveness can be influenced by other medications. In a study with rats, preadministration of lorazepam diminished the long-lasting antidepressant efficacy of psilocin. While psilocin boosted activity initially, lorazepam reduced its benefits over time.
Abstract
Psychedelics such as psilocybin have been shown to have persistent antidepressant effects, but with considerable individual variability in optimal ...