1 Article by Haohua Wang
Barrier effects on the kinetics of cohesin-mediated loop extrusion.
Biophysical journal – April 02, 2025
Summary
Cohesin plays a vital role in organizing chromosomes by forming loops, but its process can be influenced by other proteins. This study reveals that physical barriers can actually speed up loop formation, especially when close to cohesin loading sites. In contrast, chemical barriers slow it down. These findings enhance our understanding of gene regulation and chromatin organization.
Abstract
Chromosome organization mediated by structural maintenance of chromosome complexes is crucial in many organisms. Cohesin extrudes chromatin into lo...