1 Article by Ede Frecska
Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells.
PLoS ONE – June 15, 2016
Summary
Psychedelic compounds like N,N-dimethyltryptamine and its derivative 5-methoxy-N,N-dimethyltryptamine show promise in regulating inflammation. They inhibit harmful cytokines while promoting anti-inflammatory responses in human immune cells. This suggests their potential for treating autoimmune diseases and chronic inflammation, highlighting a novel role for these substances in immune regulation.
Abstract
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It ha...