2 Articles by George A Mashour
Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex.
Translational psychiatry – March 25, 2025
Summary
Psilocybin, known for altering consciousness, significantly impacts brain network dynamics. In a study with rats, varying doses revealed that psilocybin disrupts theta-gamma coupling while enhancing connectivity and network density in specific brain regions. These findings highlight how psilocybin may reshape brain organization during altered states.
Abstract
Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in cortical networks. Given t...
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Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial.
Frontiers in pain research (Lausanne, Switzerland) – January 01, 2025
Summary
In a groundbreaking pilot clinical trial, psilocybin-assisted therapy showed promising results for adults with fibromyalgia, a condition marked by widespread pain and cognitive challenges. Participants experienced significant reductions in pain severity, interference, and sleep disturbances after treatment. The therapy was well-tolerated, paving the way for future studies.
Abstract
Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread pain and issues with cognition, mood, and sleep. Curr...