1 Article by Orr Shahar
Premorbid Characteristics of the SAPAP3 Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment.
The international journal of neuropsychopharmacology – March 29, 2025
Summary
Juvenile SAPAP-3 knockout mice show anxiety-like behaviors before developing excessive self-grooming, akin to symptoms of obsessive-compulsive disorder (OCD) and Tourette’s Syndrome. While psilocybin treatment didn’t alleviate these behaviors, significant neuroplastic changes were noted in adults, highlighting important developmental patterns in OCD.
Abstract
SAPAP3-knockout (SAPAP3-KO) mice develop excessive self-grooming behavior at 4-6 months of age, serving as a model for obsessive-compulsive disorde...