1 Article by Guang Liang
Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway.
Respiratory research – March 28, 2025
Summary
Acute lung injury poses serious health risks, but harmine, a natural compound, shows promise in combating this condition. In experiments with mice, harmine reduced inflammation by inhibiting Granulocyte Colony-Stimulating factor (CSF3), effectively blocking the MAPK/NF-κB signaling pathway. These findings suggest harmine could be a safe and effective treatment for inflammatory lung diseases.
Abstract
Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid de...