1 Article by Jianhua Wang
Harmine derivative H-2-168 induces the death of Echinococcus granulosus by regulating mitochondrial fusion and fission.
Pharmaceutical biology – December 01, 2025
Summary
A promising compound, H-2-168, effectively targets Echinococcus granulosus, the parasite responsible for cystic echinococcosis. By disrupting mitochondrial balance through Drp1 regulation, it significantly reduces the parasite's viability. This innovative approach highlights a potential new strategy in combating this challenging infection.
Abstract
H-2-168 has pharmacological effects similar to those of harmine, with less toxicity. The health of cells and organisms depends on a delicate balanc...