1 Article by Massimo Trusel
Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.
International journal of molecular sciences – March 20, 2025
Summary
A synthetic psychedelic, 25I-NBOMe, significantly impacts brain function in mice. It enhances dopamine transmission and alters behavior, shown through increased reaction times and disrupted prepulse inhibition. The compound also prevents long-term potentiation in the prefrontal cortex, indicating profound effects on synaptic plasticity.
Abstract
25I-NBOMe (4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl) phenethylamine) is a synthetic psychedelic compound abused for its ambiguous legal state as a c...