1 Article by Yang Wang
The Selective 5HT2A Receptor Agonist, 25CN-NBOH Exerts Excitatory and Inhibitory Cellular Actions on Mouse Medial Prefrontal Cortical Neurons.
Synapse (New York, N.Y.) – March 01, 2025
Summary
Recent findings reveal that a synthetic psychedelic, known for its strong connection to serotonin receptors, can both excite and inhibit brain activity. In mouse brain slices, researchers recorded action potentials showing that while higher doses increased excitatory signals, they also suppressed neuron firing. This dual effect enhances our understanding of psychedelics' therapeutic potential.
Abstract
Psychedelic compounds have gained renewed interest due to their rapid and long-lasting therapeutic effects on stress-related disorders. While the u...