1 Article by Han-Ting Chen
CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure.
Behavioural brain research – May 08, 2025
Summary
Maternal inflammation during pregnancy can impact cognitive behavior in offspring, especially with rising prenatal cannabis exposure. This study reveals that the CB1 receptor plays a key role in impairments from cannabis use, while the CB2 receptor influences outcomes from maternal immune activation. Interestingly, combined exposure may protect against these effects.
Abstract
Maternal immune activation (MIA) commonly arises in response to an infection during pregnancy. MIA elevates cytokine levels, triggering an inflamma...