2 Articles by Ken Mackie
CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure.
Behavioural brain research – May 08, 2025
Summary
Maternal inflammation during pregnancy can impact cognitive behavior in offspring, especially with rising prenatal cannabis exposure. This study reveals that the CB1 receptor plays a key role in impairments from cannabis use, while the CB2 receptor influences outcomes from maternal immune activation. Interestingly, combined exposure may protect against these effects.
Abstract
Maternal immune activation (MIA) commonly arises in response to an infection during pregnancy. MIA elevates cytokine levels, triggering an inflamma...
CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice.
Pharmacological research – April 01, 2025
Summary
Synthetic cannabinoids can lead to acute respiratory failure, a risk often overlooked with THC, the main compound in cannabis. This study revealed that both THC and another cannabinoid significantly reduced breathing in mice by acting on brain regions essential for respiration. Notably, they also interacted with opioid pathways, highlighting potential overdose risks.
Abstract
Recreational use of synthetic cannabinoid agonists (i.e., "spice compounds") that target the cannabinoid type 1 receptor (CB1) can cause acute resp...