1 Article by Maya Gaines-Smith
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain.
Pharmacological research – March 17, 2025
Summary
Exciting findings reveal that psilocybin, a psychedelic compound, effectively alleviates chronic pain in mouse models. In studies involving mice with neuropathy, psilocybin significantly reduced sensitivity to mechanical and thermal pain. This effect is linked to the activation of specific receptors, suggesting a promising avenue for future pain treatments.
Abstract
Chronic pain is a debilitating disease with current treatments lacking efficacy and safety, therefore discovery of new treatments is crucial. Initi...