1 Article by Huijing Gao
Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice.
BMC veterinary research – March 17, 2025
Summary
A promising new drug candidate shows remarkable potential against a chronic parasitic disease caused by Echinococcus granulosus. A derivative of harmine, H-2-104, demonstrated superior efficacy in inhibiting the parasite compared to existing treatments. In mice, it achieved a significant cyst inhibition rate and altered key metabolic pathways, suggesting its effectiveness and safety as a treatment option.
Abstract
Cystic echinococcosis (CE) is a chronic zoonotic parasitic disease caused by the parasite Echinococcus granulosus (E. granulosus). Currently, pharm...