1 Article by Joseph H Holbrook

Light-Reactive Norharmane Derivatization of Lipid Isomers by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

Analytical chemistry – March 25, 2025

Summary

A groundbreaking technique enhances our ability to analyze complex lipid structures, crucial for understanding biological systems. By using light-reactive properties of unsaturated lipids in mass spectrometry, researchers successfully identified specific lipid isomers. This method not only improves resolution but also allows for detailed imaging in tissues and cell cultures.

Abstract

The lipidome, encompassing the comprehensive lipid fingerprint of a biological system, includes thousands of unique isomeric and isobaric lipid spe...

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