1 Article by Sadatomo Wainai
Liver-derived Neuregulin1α stimulates compensatory pancreatic β cell hyperplasia in insulin resistance.
Nature communications – March 13, 2025
Summary
A liver protein called Neuregulin1α plays a vital role in enhancing pancreatic β cell growth, especially during insulin resistance. In studies with mice, higher levels of this protein helped maintain insulin production, while its absence led to impaired glucose management. This discovery highlights Neuregulin1α's potential in addressing type 2 diabetes.
Abstract
Compensatory pancreatic islet hyperplasia is an adaptive response to increased systemic insulin demand, although factors meditating this response r...