1 Article by Shamiha T Ahmed
Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [125I]Radioiodinated DYRK1A Inhibitor.
Molecules (Basel, Switzerland) – February 21, 2025
Summary
DYRK1A, linked to Tau hyperphosphorylation in Alzheimer's disease and down syndrome, shows promise as a target for imaging. Researchers identified [125I]KuFal184 as a potential imaging agent, demonstrating its selectivity for Tau in brain slices. This advancement could lead to earlier detection of Tauopathies through autoradiography.
Abstract
Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system an...