1 Article by Matthew Garner
Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders: A Narrative Review.
JAMA psychiatry – March 12, 2025
Summary
Expectancy effects can significantly skew results in psychiatric clinical trials, influencing how treatments are perceived and their effectiveness. This review highlights how compromised blinding and treatment expectations can introduce bias. It suggests strategies to improve reliability, emphasizing the need for objective measures to better assess treatment outcomes.
Abstract
Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation o...