Increased 5-HT2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics
bioRxiv – June 13, 2024
Source: medRxiv/bioRxiv/arXiv
Summary
Recent findings reveal that the effectiveness of 5-HT2A receptor signaling sets psychedelics apart from non-psychedelics. By comparing various compounds, researchers discovered that higher signaling efficacy in psychedelics may explain their unique effects, hinting at promising avenues for treating psychiatric disorders.
Abstract
Background and Purpose Serotonergic psychedelic drugs are under renewed investigation for the potential treatment of several psychiatric disorders. While all serotonergic psychedelics have 5-HT2A receptor activity, the explanation for why some 5-HT2A receptor agonists are not psychedelic is unknown. To address this question, we investigated the 5-HT2A receptor signalling bias and efficacy of a panel of psychedelics and non-psychedelics.