Effects of serotonergic psychedelics on synaptogenesis and immediate early genes expression – comparison with ketamine, fluoxetine and lithium
bioRxiv – August 07, 2024
Source: medRxiv/bioRxiv/arXiv
Summary
Recent findings show that serotonergic psychedelics may enhance brain connectivity more effectively than traditional antidepressants. By comparing these substances to ketamine, fluoxetine, and lithium, researchers discovered that psychedelics promote synaptogenesis and activate immediate early genes, suggesting a promising avenue for treating depression.
Abstract
Background Recent evidence suggests that psychedelics are able to induce rapid and long-lasting antidepressant effects. The generally acknowledged explanation for these traits is the phenomenon of neuroplasticity, although exact underlying molecular mechanisms remain unclear.