The phenomenology of psilocybin’s experience mediates subsequent persistent psychological effects independently of sex, previous experience or setting

medRxiv – August 26, 2024

Source: medRxiv/bioRxiv/arXiv

Summary

Psilocybin, a compound found in certain mushrooms, may lead to lasting psychological benefits. This study reveals that the nature of one’s psilocybin experience significantly influences enduring positive effects, regardless of factors like sex or prior use. The findings highlight psilocybin's potential as a transformative mental health tool.

Abstract

Background Recent studies have intensively explored the potential antidepressant effects of psilocybin. However, important variables such as previous experience, repeated administration, setting and sex remain underexplored. This study describes the acute psilocybin experience and long-term effects in a small sample of healthy individuals.