Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial

medRxiv – December 31, 2024

Source: medRxiv/bioRxiv/arXiv

Summary

Frontline healthcare providers faced unprecedented stress during the COVID-19 pandemic, leading to significant depression and burnout. This trial explored the combined effects of psilocybin and mindfulness-based stress reduction (MBSR). Results showed marked improvements in mental well-being, highlighting a promising approach for recovery.

Abstract

Objective This clinical trial sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR for frontline healthcare providers with symptoms of depression and burnout related to the COVID-19 pandemic.