Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
medRxiv – November 07, 2024
Source: medRxiv/bioRxiv/arXiv
Summary
Research reveals that changes in white matter microstructure may play a role in suicidal thoughts and behaviors. A large analysis by the ENIGMA consortium found consistent alterations linked to these thoughts and actions, enhancing our understanding of their underlying neural mechanisms. This insight could inform future interventions and support strategies.
Abstract
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs.