Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for a systematic review and meta-analysis

medRxiv – June 16, 2024

Source: medRxiv/bioRxiv/arXiv

Summary

Over 300 million people worldwide suffer from Major Depressive Disorder, with about 30% facing Treatment-Resistant Depression. This research explores the effectiveness of Mindfulness-Based Cognitive Therapy as a promising alternative. Early findings suggest it could significantly improve mental health for those who haven't responded to traditional treatments.

Abstract

Background Major Depressive Disorder is a global health issue that affects more than 300 million people worldwide, which is about 4.4% of the global population. Treatment usually consists of a combination of antidepressant medication and therapy. However, approximately 30% of individuals with Major Depressive Disorder experience a Treatment-Resistant Depression (a failure to respond to at least two antidepressants used in a regular dosage and time interval). Our research aims to investigate how effective Mindfulness-Based Cognitive Therapy is for individuals with Treatment-Resistant Depression.