WENDY: Covariance Dynamics Based Gene Regulatory Network Inference
bioRxiv – April 04, 2024
Source: medRxiv/bioRxiv/arXiv
Summary
Understanding how genes regulate each other is crucial for advancements in biology. A new method effectively analyzes single-cell gene expression data over time, revealing intricate regulatory relationships. By modeling covariance dynamics, this approach outperforms existing techniques, showcasing its potential to enhance genetic research and insights.
Abstract
Determining gene regulatory network (GRN) structure is a central problem in biology, with a variety of inference methods available for different types of data. For a widely prevalent and challenging use case, namely single-cell gene expression data measured after intervention at multiple time points with unknown joint distributions, there is only one known specifically developed method, which does not fully utilize the rich information contained in this data type. We develop an inference method for the GRN in this case, netWork infErence by covariaNce DYnamics, dubbed WENDY. The core idea of WENDY is to model the dynamics of the covariance matrix, and solve this dynamics as an optimization problem to determine the regulatory relationships. To evaluate its effectiveness, we compare WENDY with other inference methods using synthetic data and experimental data. Our results demonstrate that WENDY performs well across different data sets.