Articles
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
Journal of psychiatric research – April 01, 2025
Summary
Psychedelic experiences can enhance mindfulness and self-compassion, promoting healthier meditation practices. In a study of over 13,000 participants, those who used psychedelics reported increased compassion meditation, especially if they were new to both psychedelics and meditation. This suggests positive associations that may reduce adverse experiences and harm.
Abstract
Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitu...
Fluorescent Spectrofluorimetric Method for the Quantification of Harmine in Human Plasma Using Tinopal CBS-X.
Luminescence : the journal of biological and chemical luminescence – April 01, 2025
Summary
Harmine, a plant-derived compound with promising therapeutic benefits, can now be accurately measured in human plasma thanks to an innovative method using Tinopal CBS-X. This fluorescent spectroscopy approach detects harmine as low as 1 nanogram/mL, ensuring reliable results without interference from plasma components.
Abstract
Harmine, a β-carboline alkaloid derived from plants like Banisteriopsis caapi and Peganum harmala, possesses significant pharmacological properties...
Medical Cannabis in the United States: Comparing 2017 and 2024 State Qualifying Conditions to the 2017 National Academies of Sciences Report.
Mayo Clinic proceedings. Innovations, quality & outcomes – April 01, 2025
Summary
In 2024, nearly all states listed qualifying conditions for medical cannabis, with a significant increase in those citing substantial evidence since 2017. However, only a small fraction of these conditions are backed by strong research. This gap reveals a need for more robust evidence to support state-level medical cannabis recommendations.
Abstract
To compare the 2017 National Academies of Sciences, Engineering, and Medicine cannabis report to state medical cannabis (MC) laws defining approved...
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De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli.
Microbial biotechnology – April 01, 2025
Summary
Psilocybin, a promising treatment for depression, can now be sustainably produced in E. coli. By engineering the cytochrome P450 enzyme and optimizing the electron transfer chain, researchers achieved a remarkable 100-fold increase in psilocybin yield. This innovative pathway engineering opens doors for efficient, heterologous production of this vital tryptamine-derived alkaloid.
Abstract
Psilocybin, a tryptamine-derived alkaloid, has been granted Breakthrough Therapy designation by the U.S. FDA for treatment-resistant depression, un...
Siddha medicine and modern neuroscience: a synergistic approach to neurological care.
3 Biotech – April 01, 2025
Summary
Neurological disorders pose significant challenges, but an integrative approach combining Siddha herbal medicine with modern neuroscience shows promise. This review highlights how Siddha therapies—both neuromodulatory and neuroprotective—can enhance brain function and quality of life through non-invasive methods like yoga and meditation. Embracing this synergy could transform neurological care.
Abstract
Neurological disorders burden modern healthcare causing cognitive and emotional issues. The Siddha system offers a promising herbal and non-invasiv...
High Stakes: Exploring the Impact of Cannabis Use in Pregnancy and Lactation.
NeoReviews – April 01, 2025
Summary
Cannabis use during pregnancy is surprisingly common, with estimates showing 3% to 30% of expectant mothers using it. This review highlights the effects of delta-9-tetrahydrocannabinol, the main active ingredient, on fetal and infant health. It offers evidence-based counseling strategies for safer practices during pregnancy and breastfeeding.
Abstract
Cannabis is the most commonly used federally illicit substance during pregnancy in the United States, with an estimated prevalence of 3% to 30%. Th...
The Sustained Attention Paradox: A Critical Commentary on the Theoretical Impossibility of Perfect Vigilance.
Cognitive science – April 01, 2025
Summary
Maintaining perfect vigilance is a cognitive challenge; even the most skilled individuals experience attention lapses over time. This commentary highlights how our neural and cognitive limitations make sustained attention difficult. It advocates for designing human-technology systems that complement these constraints, enhancing performance in critical tasks.
Abstract
The human capacity for sustained attention represents a critical cognitive paradox: while essential for numerous high-stakes tasks, perfect vigilan...
Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model.
Journal of psychopharmacology (Oxford, England) – April 01, 2025
Summary
Nearly 1 billion people suffer from anxiety and depression, but new insights suggest MDMA may help. In a study using young zebrafish (Danio rerio), researchers found that MDMA reduced anxiety behaviors and enhanced social interactions. The oxytocin system played a key role, indicating a promising avenue for treatment.
Abstract
Mental disorders, including anxiety and depression, impact nearly 1 billion people worldwide. Recent research has highlighted the potential of cert...
Psilocybin Dispensaries and Online Health Claims in Canada.
JAMA network open – April 01, 2025
Summary
In May 2024, Canada had 57 psilocybin dispensaries, primarily in Ontario and British Columbia, revealing a growing market despite legal restrictions. While many stores claimed mental health benefits, they often overlooked crucial safety warnings. This highlights the need for better regulations to ensure public safety amid rising interest in psilocybin.
Abstract
There is growing societal interest in and use of psilocybin. While psilocybin in Canada is illegal outside of clinical trials, there have been anec...
Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial.
EClinicalMedicine – April 01, 2025
Summary
A single dose of psilocybin, paired with brief psychotherapy, was tested for its potential to reduce relapse in alcohol use disorder. In a randomized clinical trial with 37 participants, results showed no significant differences in abstinence or alcohol consumption between the psilocybin and placebo groups. However, both groups reported decreased cravings, hinting at possible benefits of psychedelic-assisted therapy in addiction treatment.
Abstract
Despite the promising therapeutic effects of psilocybin, its efficacy in preventing relapse after withdrawal treatment for alcohol use disorder (AU...
Case Study: An Integrative Modification of Gut-Directed Hypnotherapy for a Patient with Intermittent Flares of Long-Standing Irritable Bowel Syndrome.
The International journal of clinical and experimental hypnosis – April 01, 2025
Summary
A patient with long-standing irritable bowel syndrome found relief through an innovative approach combining gut-directed hypnosis with mindfulness and narrative therapy. This integrative psychotherapy effectively reduced gastrointestinal flare-ups, showcasing the potential of tailored hypnotherapy in managing IBS symptoms.
Abstract
This article presents a case of a patient whose treatment for irritable bowel syndrome (IBS) involved a modification of gut-directed hypnotherapy (...
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The appetite stimulating effect and safety of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in older patients with poor appetite: A triple-blinded, randomized, placebo-controlled, cross-over trial.
Clinical nutrition (Edinburgh, Scotland) – April 01, 2025
Summary
Anorexia of aging can lead to malnutrition in older patients, making effective appetite stimulants crucial. A recent trial tested a cannabis-based medicine combining THC and CBD, aiming to boost caloric intake. While no significant increase in appetite was found, the treatment was generally well-tolerated, highlighting its safety for this demographic.
Abstract
Anorexia of aging is prevalent and constitutes a significant factor in the onset of malnutrition with limited effective interventions. Cannabis-bas...
Psychedelics, spirituality, and existential distress in patients at the end of life.
Cleveland Clinic journal of medicine – April 01, 2025
Summary
Psychedelics may offer profound relief for patients facing existential distress at the end of life. Recent insights suggest these substances can enhance spirituality and alleviate deep-seated fears associated with dying. This exploration encourages a broader conversation about their potential therapeutic use in end-of-life care.
Abstract
Psychedelic-assisted therapy clinical trials conducted over the past decade have prompted increased interest in the use of psychedelics to treat no...
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[Promoting Self-Care and Resilience in High-Stress Nursing Workplaces].
Hu li za zhi The journal of nursing – April 01, 2025
Summary
Nurses face significant burnout, with many under 25 experiencing it at alarming rates. This study highlights effective self-care and resilience strategies, like mindfulness and virtual reality meditation, to combat stress in high-pressure environments. Such interventions promote well-being, enhance job satisfaction, and improve patient care outcomes.
Abstract
Staffing shortages and excessive workloads are issues faced by nurses worldwide. In the United States, 62% of nurses experience burnout, with burno...
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[The Power of Gratitude: A Key to Enhance Mental Health in Nurses and Improve Retention].
Hu li za zhi The journal of nursing – April 01, 2025
Summary
Gratitude can be a game-changer for nurses, boosting their mental health and job retention. By practicing gratitude through activities like journaling and team gatherings, nurses can reduce stress, enhance well-being, and improve workplace relationships. Embracing these practices could lead to happier, more stable nursing teams.
Abstract
The impact of gratitude on mental health and job stability in nurses is explored in this article, with a focus on relevant challenges and potential...
The efficacy of psychotherapeutic interventions for prolonged grief disorder: A systematic review.
Journal of affective disorders – April 01, 2025
Summary
Prolonged grief disorder (PGD) affects 9.8% to 34.3% of bereaved individuals, often leading to significant emotional and social challenges. A systematic review of 30 randomized controlled trials highlights that psychotherapeutic interventions, particularly Cognitive Behavioral Therapy (CBT), effectively alleviate PGD symptoms. Innovative combinations of CBT with mindfulness and trauma-focused therapies show promise, enhancing recovery pathways. This underscores the value of tailored, accessible treatments for those experiencing complex grief, paving the way for improved mental health outcomes.
Abstract
Prolonged Grief Disorder (PGD), newly recognized in the ICD-11 and DSM-5-TR, represents a severe and persistent bereavement response that disrupts ...
Direct mapping of intervention to thought features: A Bayesian proof-of-concept study.
Behaviour research and therapy – April 01, 2025
Summary
Uncontrollable thoughts significantly impact mental health, but some strategies can help manage them. A study with 40 adults focused on how different features of worry predict the effectiveness of mindfulness or thought suppression techniques. Results showed mindfulness was especially beneficial for managing highly uncontrollable worries, highlighting its potential in therapeutic settings.
Abstract
Although uncontrollability is the core feature of perseverative thought that best accounts for its relationship to psychopathology, other features ...
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A neuroscientific model of near-death experiences.
Nature reviews. Neurology – March 31, 2025
Summary
Near-death experiences often involve vivid, mystical sensations during life-threatening situations. This study proposes a model integrating psychological and neurophysiological insights to explain these phenomena. By examining brain activity and neurotransmitter changes, the findings suggest a complex interplay of factors that shape consciousness during such critical moments.
Abstract
Near-death experiences (NDEs) are episodes of disconnected consciousness that typically occur in situations that involve an actual or potential phy...
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Sporadic use of classic psychedelics and neuropsychological performance: A cross-sectional analysis.
Progress in neuro-psychopharmacology & biological psychiatry – March 31, 2025
Summary
Sporadic use of psychedelics like psilocybin and LSD may enhance cognitive flexibility. In a study with 136 participants, those who used psychedelics showed improved executive function, particularly in tasks requiring problem-solving. Overall, there were no negative effects on neuropsychological performance, highlighting potential benefits.
Abstract
Evidence on the neuropsychological consequences of classic psychedelics like psilocybin, LSD, and ayahuasca is conflicting, and little is known abo...
Do Complications Weight on Surgeons? Second Victim Syndrome in Metabolic and Bariatric Surgery.
Obesity surgery – March 31, 2025
Summary
Serious complications in surgery not only impact patients but also take a toll on surgeons' mental health. A survey of 130 metabolic and bariatric surgeons revealed that many experience guilt, anxiety, and sleep issues after adverse events. Women and younger surgeons are particularly affected. The study underscores the urgent need for better support systems to help surgeons cope effectively.
Abstract
Although complications primarily affect patients, they also seem to cause repetitive trauma for surgeons. The concept of the "second victim" was in...
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Pilot randomized controlled trial of MINDful TIME, a novel telehealth mindfulness-based intervention for autistic adolescents and their caregivers.
Autism : the international journal of research and practice – March 31, 2025
Summary
Mindfulness training can significantly benefit autistic adolescents and their caregivers. A novel telehealth program, featuring eight weekly sessions via Zoom and a mindfulness mobile app, showed that participants experienced notable reductions in depression and anxiety symptoms. High completion rates and positive feedback highlight its promise for enhancing mental well-being in this community.
Abstract
A growing body of research suggests that mindfulness-based interventions may be a valuable method for reducing internalizing symptoms in autistic i...
Utilizing Psychedelics to Enhance Well-Being: A Systematic Review.
Journal of psychoactive drugs – March 31, 2025
Summary
Psychedelics show promise not just for treating mental health issues but also for enhancing overall well-being. This review highlights how substances like psilocybin and ayahuasca can boost the five elements of PERMA—positive emotions, engagement, relationships, meaning, and accomplishment—promoting self-actualization and neuroplasticity.
Abstract
Psychedelic-assisted therapy is gaining recognition for its potential to enhance human functioning. While most research has focused on psychedelic'...
Longitudinal associations of naturalistic psychedelic use with psychotic and manic symptoms.
Psychological medicine – March 31, 2025
Summary
Engaging with psychedelics outside clinical settings may carry risks, especially for those with a history of schizophrenia or bipolar disorder. A study found that illegal psychedelic use linked to increased psychotic and manic symptoms, depending on frequency and personal experiences. Insights gained during these experiences could mitigate some risks.
Abstract
Findings from contemporary clinical trials suggest that psychedelics are generally safe and may be effective in the treatment of various psychiatri...
Development and Initial Validation of the State Four Facet Mindfulness Questionnaire.
Assessment – March 31, 2025
Summary
Mindfulness can enhance well-being, and a new tool, the State Four Facet Mindfulness Questionnaire (state-4FMQ), effectively measures this. Developed through rigorous testing, it reveals a strong four-factor structure and shows excellent psychometric properties. This assessment promises to deepen our understanding of mindfulness in various contexts.
Abstract
The current research aimed to provide initial psychometric validation of a new multifaceted mindfulness questionnaire (referred to as the State Fou...
The Afterglow Inventory (AGI): Validation of a new instrument for measuring subacute effects of classic serotonergic psychedelics.
Journal of psychopharmacology (Oxford, England) – March 31, 2025
Summary
Classic psychedelics often leave users with a pleasant "afterglow"—a period of enhanced well-being after the main effects fade. To explore this, researchers developed a new questionnaire to assess subacute effects. Their study found that the Afterglow Inventory effectively measures positive outcomes, revealing connections between acute experiences and lasting benefits.
Abstract
Classic psychedelics such as psilocybin and lysergic acid diethylamide are anecdotally associated with the phenomenon of "psychedelic afterglow," a...
Prevalence of HIV in sex workers attended in a health institution in Medellín, Colombia.
International journal of STD & AIDS – March 31, 2025
Summary
In Medellín, the prevalence of human immunodeficiency virus (HIV) among female sex workers is notably higher than previously reported, at 1.4%. This study highlights that those with prior sexually transmitted infections face a 12% prevalence rate. Tailored health programs are essential to address this vulnerable group's needs effectively.
Abstract
BackgroundDespite being a key group for infection control, research on the prevalence of human immunodeficiency virus (HIV) among female sex sorker...
Deep graph learning of multimodal brain networks defines treatment-predictive signatures in major depression.
Molecular psychiatry – March 31, 2025
Summary
Major depressive disorder affects millions, often with low treatment success. By analyzing brain connectivity data from patients on sertraline and placebo, researchers developed a deep learning model that predicts treatment responses. Key brain regions were identified, offering insights into personalized interventions for better outcomes in depression treatment.
Abstract
Major depressive disorder (MDD) presents a substantial health burden with low treatment response rates. Predicting antidepressant efficacy is chall...
Premorbid Characteristics of the SAPAP3 Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment.
The international journal of neuropsychopharmacology – March 29, 2025
Summary
Juvenile SAPAP-3 knockout mice show anxiety-like behaviors before developing excessive self-grooming, akin to symptoms of obsessive-compulsive disorder (OCD) and Tourette’s Syndrome. While psilocybin treatment didn’t alleviate these behaviors, significant neuroplastic changes were noted in adults, highlighting important developmental patterns in OCD.
Abstract
SAPAP3-knockout (SAPAP3-KO) mice develop excessive self-grooming behavior at 4-6 months of age, serving as a model for obsessive-compulsive disorde...
Assessing willingness and preference for body scan practices in ADHD: a survey study.
BMC complementary medicine and therapies – March 29, 2025
Summary
Many adults with ADHD are open to exploring body scan practices as a potential treatment. A recent survey revealed that while most participants weren't currently practicing mindfulness, they were willing to try meditation and believed it feasible. Preferences leaned towards professional classes and 1-2 sessions weekly, highlighting a promising path for integrating these techniques into ADHD management.
Abstract
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition, but current treatment options are limited. Although medic...
Perceived Impact of Psychedelics on Sexual, Gender, and Intimate Relationship Dynamics: A Mixed-Methods Investigation.
Journal of sex research – March 28, 2025
Summary
Psychedelics have been reported to positively influence sexuality and intimate relationships, with 70% of users noting beneficial effects. Many experienced enhanced attraction and relationship quality, while some reported shifts in gender identity and sexual orientation. These substances appear to promote self-acceptance and deeper connections.
Abstract
Systematic research on the impact of psychedelic use on sexuality and intimacy remains limited. This study investigated reported effects of psyched...