Articles
Insights on Psychedelics: A Systematic Review of Therapeutic Effects.
Neuroscience and biobehavioral reviews – March 22, 2025
Summary
Psychedelics often lead to profound insights that can significantly enhance mental health. A review of 98 studies reveals that these insights, typically stronger with higher doses, correlate with improved well-being in 86% of cases. This suggests that fostering such experiences could be key to effective therapeutic practices.
Abstract
Insight - a sudden change in understanding or perspective that feels true or reliable - is a common occurrence during psychedelic experiences, and ...
Virtual reality based mindfulness applications: a commercial health app review
medRxiv – March 21, 2025
Summary
Mindfulness can enhance well-being, but traditional programs often fall short due to accessibility and cost. This review found that virtual reality applications provide immersive experiences that significantly boost mindfulness practices. Users reported improved mental health and relaxation, making VR a promising tool for enhancing well-being.
Abstract
Introduction Mindfulness can positively impact physical and mental health, but face-to-face programmes are limited by poor accessibility, availabil...
LSD reconfigures the frequency-specific network landscape of the human brain
bioRxiv – March 21, 2025
Summary
LSD significantly transforms how our brain networks communicate, enhancing high-frequency activity while diminishing lower frequencies. In a study with 14 participants, researchers found that LSD shifts brain activity patterns, particularly in visual and motor areas, revealing its unique impact on consciousness and connectivity.
Abstract
Lysergic acid diethylamide (LSD) and other psychedelic substances profoundly alter human consciousness. While several studies have demonstrated cha...
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Hype or hope? The developing evidence base for psychedelic treatment of addiction disorders.
The British journal of psychiatry : the journal of mental science – March 21, 2025
Summary
Recent studies highlight the promising role of psychedelics in treating addictions. Clinical trials show these compounds can significantly reduce substance use disorders, offering hope for effective, evidence-based mental health solutions. This emerging approach could reshape addiction treatment and improve patient outcomes.
Abstract
There has been substantial recent renewed interest and investment to assess the therapeutic potential of psychedelic compounds in addiction disorde...
Is there a place for psychedelics in sports practice?
Acta neuropsychiatrica – March 21, 2025
Summary
Psychedelics like psilocybin and MDMA may enhance athletes' resilience by reducing inflammation and pain, while promoting neuroplasticity. With their potential to elevate serotonin levels, these substances could improve mental health, crucial for high-pressure sports. Exploring their effects on performance warrants attention for future athletic practices.
Abstract
Growing evidence suggests that psychedelic-assisted therapies can alleviate depression, anxiety, posttraumatic stress, and substance use disorder, ...
The effects of mindfulness on working memory: a systematic review and meta-analysis
bioRxiv – March 21, 2025
Summary
Mindfulness practices can boost our working memory, a vital cognitive skill. This review analyzed numerous studies and found that mindfulness significantly enhances working memory across different ages and health conditions. Embracing mindfulness not only promotes mental well-being but also sharpens our ability to retain and process information effectively.
Abstract
Objectives Mindfulness is a promising health intervention, showing potential effects on cognitive functions like memory. Despite evidence suggestin...
Regulation of Stress Physiology While Parenting: a Randomized Micro-trial of Loving-Kindness Meditation on Parenting and Salivary Alpha Amylase.
Prevention science : the official journal of the Society for Prevention Research – March 20, 2025
Summary
Sensitive parenting fosters healthy child development, particularly during toddlerhood. A micro-trial exploring loving-kindness meditation revealed that while it didn't significantly boost parental sensitivity, it effectively lowered salivary alpha amylase levels, indicating reduced stress. This suggests that cultivating compassion can positively impact parents' stress responses while engaging with their children.
Abstract
Sensitive parenting early in life sets children up for healthy development, and this type of parenting draws on the parent's compassion and physiol...
Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning-Based Advanced Perspectives.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) – March 20, 2025
Summary
Psychedelic drugs like psilocybin and LSD show promise as innovative treatments for mental disorders such as depression and anxiety. By leveraging artificial intelligence and deep learning, researchers are uncovering how these substances interact with the brain’s transcriptome. This approach enhances drug development, paving the way for tailored therapies that could revolutionize mental health care.
Abstract
Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (A...
Polysubstance Use Profiles Among the General Adult Population, United States, 2022: A Latent Class Analysis.
American journal of public health – March 20, 2025
Summary
In 2022, nearly 21% of U.S. adults reported using multiple substances, revealing diverse patterns of polysubstance use. The study identified four distinct profiles, highlighting the need for personalized prevention and treatment strategies. Understanding these patterns can enhance support for individuals struggling with substance use disorders.
Abstract
Objectives. To characterize present-day polysubstance use patterns in the general adult population. Methods. From a 2022 nationally representative ...
Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.
International journal of molecular sciences – March 20, 2025
Summary
A synthetic psychedelic, 25I-NBOMe, significantly impacts brain function in mice. It enhances dopamine transmission and alters behavior, shown through increased reaction times and disrupted prepulse inhibition. The compound also prevents long-term potentiation in the prefrontal cortex, indicating profound effects on synaptic plasticity.
Abstract
25I-NBOMe (4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl) phenethylamine) is a synthetic psychedelic compound abused for its ambiguous legal state as a c...
Meta-analysis of age at help-seeking and duration of untreated illness (DUI) in obsessive-compulsive disorder (OCD): The need for early interventions.
Journal of affective disorders – March 19, 2025
Summary
Individuals with obsessive-compulsive disorder (OCD) often wait nearly 7 years to seek help, leading to a long duration of untreated illness (DUI) that negatively impacts recovery. This analysis highlights the importance of early intervention, revealing that specific factors influence both help-seeking and DUI, emphasizing the need for timely support.
Abstract
Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder that often begins early in childhood. Patients with OCD are known to see...
Proximal Effects of a Just-in-Time Adaptive Intervention for Smoking Cessation With Wearable Sensors: Microrandomized Trial.
JMIR mHealth and uHealth – March 19, 2025
Summary
Tobacco use is a major health threat, but innovative strategies can aid quitting. A recent microrandomized trial tested a mindfulness-based Just-in-Time Adaptive Intervention (JITAI) delivered via mobile phones, combined with nicotine replacement therapy and counseling. Participants reported lower negative affect and increased self-efficacy for abstinence during the intervention, highlighting the potential of adaptive interventions to support smokers in their cessation journey.
Abstract
Tobacco use remains the leading preventable cause of morbidity and mortality in the United States. Novel interventions are needed to improve smokin...
Cross-Frequency Coupling as a Neural Substrate for Prediction Error Evaluation: A Laminar Neural Mass Modeling Approach
bioRxiv – March 19, 2025
Summary
Neural computations may hinge on how brain waves interact. This study reveals that cross-frequency coupling (CFC) helps evaluate prediction errors, crucial for processing sensory information. By modeling brain activity, researchers found that disruptions in CFC can lead to issues in conditions like Alzheimer’s and highlight potential therapeutic avenues with psychedelics.
Abstract
Predictive coding frameworks suggest that neural computations rely on hierarchical error minimization, where sensory signals are evaluated against ...
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The structural diversity of psychedelic drug actions revealed.
Nature communications – March 19, 2025
Summary
Recent insights into psychedelics reveal their diverse actions on the 5-HT2A serotonin receptor, a key player in treating conditions like depression and anxiety. By analyzing various compounds, researchers identified unique molecular interactions, paving the way for new therapies that could offer benefits with fewer side effects.
Abstract
There is currently a resurgence in exploring the utility of classical psychedelics to treat depression, addiction, anxiety disorders, cluster heada...
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Consensus-Based Recommendations for Yoga as Adjunct Therapy in Eating Disorder Treatment: A Delphi Study.
The International journal of eating disorders – March 19, 2025
Summary
A collaborative effort among eating disorder clinicians and yoga instructors has led to valuable recommendations for integrating yoga into treatment for anorexia nervosa, bulimia nervosa, and binge-eating disorder. Utilizing a modified Delphi technique, experts identified essential safety measures and therapeutic practices. The resulting consensus-based statements highlight tailored approaches, emphasizing yoga's potential benefits for mental health while ensuring safety in various settings.
Abstract
This study aimed to develop consensus-based statements, combining the expertise of eating disorder (ED) clinicians and yoga instructors, on key con...
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults: A Randomized Clinical Trial.
JAMA psychiatry – March 19, 2025
Summary
Microdosing with LSD shows promise for ADHD treatment, yet this study found it no more effective than a placebo. Over six weeks, adults receiving low doses of LSD reported similar symptom improvements as those on placebo. While safe and well-tolerated, LSD didn't outperform standard treatments in alleviating ADHD symptoms.
Abstract
Microdosing psychedelics, including lysergic acid diethylamide (LSD), has gained attention for its potential benefits in several psychiatric disord...
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Psychophysiological correlates of learner-instructor interaction: A scoping review.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology – March 18, 2025
Summary
Engaging with instructors can enhance learning, as shown by studies linking eye-tracking and neuroimaging to positive outcomes. Notably, inter-brain synchronization boosts social learning, while students' gaze patterns reveal their attention levels. Additionally, heart rate and peripheral physiology indicate emotional engagement, highlighting effective teaching strategies.
Abstract
This article reviews recent studies of real-time learner-instructor interactions and psychophysiological indicators associated with this process. T...
Exploring the potential of psychedelic-assisted psychotherapy for moral injury: A scoping review.
Progress in neuro-psychopharmacology & biological psychiatry – March 18, 2025
Summary
Psychedelic-assisted psychotherapy is emerging as a promising approach to address moral injury, a deep psychological distress often linked to PTSD. Studies using psilocybin, MDMA, and LSD show significant improvements in self-compassion and self-forgiveness, suggesting these psychedelics could effectively support healing from moral injury.
Abstract
This scoping review addresses the need to comprehensively explore the potential of psychedelic-assisted psychotherapy (PAP) to facilitate recovery ...
Meditation induces shifts in neural oscillations, brain complexity and critical dynamics: Novel insights from MEG
bioRxiv – March 18, 2025
Summary
Meditation doesn't just calm the mind; it reshapes brain activity. Researchers studied expert monks using advanced techniques to reveal that both focused attention and open monitoring practices increase neural complexity while decreasing certain gamma oscillations. This suggests unique brain dynamics for different meditation styles, enhancing our understanding of their benefits.
Abstract
While the beneficial impacts of meditation are increasingly acknowledged, its underlying neural mechanisms remain poorly understood. We examined th...
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The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex.
Molecular brain – March 18, 2025
Summary
Psilocybin, a compound in certain mushrooms, significantly alters gene activity in the visual cortex, much like light exposure does. In mice, both psilocybin and light triggered similar changes in genes linked to vision and neuron function, highlighting their potential to enhance visual perception together. This discovery opens new avenues for understanding visual processing.
Abstract
Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in hu...
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The Effect of Meditation-Based Mind-Body Interventions on Older Adults with Poor Sleep Quality: A Meta-Analysis of Randomized Controlled Trials.
Behavioral sleep medicine – March 18, 2025
Summary
Did you know that meditation practices like yoga and Tai Chi can significantly enhance sleep quality in older adults? A recent analysis of 11 studies with over 1,000 participants found that these mind-body interventions notably improved sleep, reduced depression, and eased anxiety. Embracing these techniques could lead to a better quality of life for many seniors.
Abstract
This study aims to evaluate the effect of meditation-based mind-body interventions (MBIs) (Mindfulness, Tai Chi, Yoga, and Qigong) for older adults...
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Therapeutic and Structural Dimensions in Psychiatric Prescribing: Bridging Psychedelics and Antidepressants.
Harvard review of psychiatry – March 18, 2025
Summary
Personalized psychiatric care is gaining traction, highlighting how a patient's environment and relationships can enhance recovery. This study explores the vital role of the therapeutic alliance between patients and clinicians in prescribing antidepressants and psychedelics, emphasizing that supportive interactions can boost treatment effectiveness and neuroplasticity.
Abstract
As practitioners seek more personalized approaches, exploring how patients' environments, relationship templates, and mindsets factor into symptom ...
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Identifying Common Patterns in the Time of Day of Mindfulness Meditation Associated with Long-Term Maintenance.
Behavioral sciences (Basel, Switzerland) – March 18, 2025
Summary
Practicing mindfulness meditation at the same time each day can enhance long-term engagement with meditation apps. Analyzing data from 15,000 users revealed that about 40% maintained consistent meditation times, which positively influenced app use. This highlights the importance of habit formation and suggests that other strategies may also support behavior maintenance.
Abstract
Forming a habit of practicing mindfulness meditation around the same time of day is one strategy that may support long-term maintenance and in turn...
Determinants of Qigong, Tai Chi, and Yoga Use for Health Conditions: A Systematic Review Protocol
medRxiv – March 18, 2025
Summary
Mind-body practices like qi gong, tai chi, and yoga can significantly enhance health outcomes, yet their adoption in healthcare is surprisingly low. This review aims to identify the barriers and facilitators influencing their use across various health conditions and settings. By understanding these factors, we can promote better integration into healthcare systems, ultimately improving patient care and accessibility.
Abstract
INTRODUCTION: Mind-body movement interventions such as qi gong, tai chi, and yoga are recommended in clinical practice guidelines to improve outcom...
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Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice.
BMC veterinary research – March 17, 2025
Summary
A promising new drug candidate shows remarkable potential against a chronic parasitic disease caused by Echinococcus granulosus. A derivative of harmine, H-2-104, demonstrated superior efficacy in inhibiting the parasite compared to existing treatments. In mice, it achieved a significant cyst inhibition rate and altered key metabolic pathways, suggesting its effectiveness and safety as a treatment option.
Abstract
Cystic echinococcosis (CE) is a chronic zoonotic parasitic disease caused by the parasite Echinococcus granulosus (E. granulosus). Currently, pharm...
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Substance use patterns among U.S. adults with HIV: identifying priorities for screening and interventions.
AIDS care – March 17, 2025
Summary
People with HIV face higher rates of substance use, particularly among younger and urban populations. A recent analysis of national data reveals that targeted interventions can significantly improve health outcomes. By focusing on harm reduction and expanding treatment access, we can promote good health and well-being while reducing inequalities for those affected.
Abstract
Given the significant syndemic of HIV and substance use in the U.S., this study sought to examine substance use patterns (consistent user, former u...
Psychedelics and autobiographical memory - six open questions.
Psychopharmacology – March 17, 2025
Summary
Psychedelics like LSD and psilocybin may enhance our ability to recall and process autobiographical memories, potentially aiding therapy. This exploration raises intriguing questions about how these substances influence memory accuracy and emotional healing. Understanding these connections could optimize therapeutic interventions, making them more effective.
Abstract
Since the earliest LSD research, psychedelics have been claimed to enhance autobiographical memory. Revisiting and processing autobiographical memo...
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain.
Pharmacological research – March 17, 2025
Summary
Exciting findings reveal that psilocybin, a psychedelic compound, effectively alleviates chronic pain in mouse models. In studies involving mice with neuropathy, psilocybin significantly reduced sensitivity to mechanical and thermal pain. This effect is linked to the activation of specific receptors, suggesting a promising avenue for future pain treatments.
Abstract
Chronic pain is a debilitating disease with current treatments lacking efficacy and safety, therefore discovery of new treatments is crucial. Initi...
The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial
medRxiv – March 17, 2025
Summary
In a groundbreaking study, patients with Major Depressive Disorder showed significant improvement in optimism after psilocybin therapy, unlike those on escitalopram. Two doses of psilocybin led to enhanced positive thinking and reduced negative biases, highlighting its potential as a more effective treatment for depression.
Abstract
Background: Patients with Major Depressive Disorder (MDD) have more dysfunctional attitudes and pessimism than healthy individuals and these biases...
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Analysis of N,N-dimethyltryptamine (DMT) and its metabolites using LC-MS/MS for forensic purposes.
Journal of forensic sciences – March 16, 2025
Summary
Ayahuasca's key ingredient, N,N-dimethyltryptamine (DMT), is rapidly metabolized in the body. Researchers developed a precise LC-MS/MS method to measure DMT and its metabolites, including N,N-dimethyltryptamine-N-oxide and indole-3-acetic acid, in human plasma and urine. Findings reveal that urine shows higher concentrations of these compounds, suggesting their potential as reliable biomarkers for forensic analysis of DMT use.
Abstract
Ayahuasca contains N,N-dimethyltryptamine (DMT), the primary alkaloid responsible for its psychedelic effects. DMT oxidative deamination yields ind...