Articles
Restoring vigilance in multi-task scenarios: a comparison of meditation, exposure to nature, music, and action video games.
Ergonomics – March 09, 2025
Summary
Engaging in restorative activities can significantly enhance our vigilance during multitasking. This study found that meditation, nature exposure, music, and action video games all improved sustained attention after initial performance declines. Meditation was the most effective, boosting executive control and reducing emotional stress, while music elevated arousal levels.
Abstract
This study aimed to investigate the cognitive mechanisms behind vigilance changes in multi-task scenarios. Moreover, we compared the effects of fou...
It's in the water: A qualitative exploration of the perceived effects of outdoor open water swimming on swimmers' psychological well-being.
Psychology of sport and exercise – March 08, 2025
Summary
Outdoor swimming in natural waters is more than just a leisure activity; it can significantly enhance psychological well-being. Interviews with swimmers revealed that this outdoor exercise fosters emotional regulation and connection to nature, aligning with social prescribing goals. The experience promotes relaxation, reflection, and even pain relief, highlighting the positive impact of "blue space" on mental health.
Abstract
Outdoor swimming for both leisure and physical exercise is a fast-growing activity in the United Kingdom. However, research into the perceived effe...
Current evidence for the role of rapid-acting antidepressants (RAAD) in bipolar depression? A perspective and plan for action.
Biological psychiatry – March 08, 2025
Summary
Recent advancements in rapid-acting antidepressants (RAADs) offer hope for treating bipolar depression, a condition often overlooked. These treatments, including NMDA antagonists like ketamine, show promise in enhancing recovery by targeting glutamate pathways. Expanding research in this area could significantly improve outcomes for those struggling with bipolar disorder.
Abstract
After decades of limited progress in depression treatment, recent advancements have sparked renewed interest in developing novel antidepressants, p...
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Psilocybin for disorders of consciousness: A case-report study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology – March 08, 2025
Summary
In a groundbreaking case, psilocybin was administered to a patient in a minimally conscious state due to severe brain injury. While traditional behavioral assessments showed no improvement, the treatment sparked new spontaneous behaviors and enhanced brain complexity. This intriguing finding opens avenues for psychedelics as a potential therapy for disorders of consciousness.
Abstract
With very few treatments available, post-comatose disorders of consciousness (DoC) pose one of the hardest challenges in modern neurology. Followin...
Mindfulness and Objective Measures of Body Awareness: A Preregistered Systematic Review and Multilevel Meta-Analysis.
Biopsychosocial science and medicine – March 07, 2025
Summary
Mindfulness practices enhance our connection to bodily sensations, and recent findings show a small positive link between mindfulness and body awareness accuracy. Analyzing 41 studies with over 2,400 participants, researchers found that long-term meditators showed improved interoceptive skills. This insight could refine mindfulness applications in clinical settings.
Abstract
Bodily sensations are a key element in many mindfulness practices. Previous meta-analytic evidence indicated a small positive association between m...
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins
bioRxiv – March 07, 2025
Summary
Single-stranded DNA-binding proteins (SSBs) are essential for protecting vulnerable DNA strands during replication. This study reveals that DNA polymerase actively displaces these SSBs in a sequential manner, enhancing replication efficiency. Using advanced imaging techniques, researchers showed that SSBs remain stationary as DNA polymerase approaches, facilitating smoother replication. This dynamic interaction ensures genomic stability and may be a common strategy among various DNA-related processes.
Abstract
Single-stranded DNA-binding proteins (SSBs) play a crucial role in stabilizing and protecting transiently exposed single-stranded DNA (ssDNA), yet ...
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Experience after Floatation-REST: Relaxation during floating mediates the afterglow effect.
Consciousness and cognition – March 07, 2025
Summary
Experiencing Floatation-REST can lead to a remarkable afterglow, enhancing relaxation and mindfulness. In a study with 34 participants, those who floated in a sensory-reduced environment reported weaker body boundaries and altered time perception. This relaxation during floating was key to the heightened afterglow effect, suggesting profound benefits for well-being.
Abstract
The term "afterglow" originally described the heightened mood and relaxation following psychedelics and later extended to other altered states. Des...
Comparison of cognitive behavioral therapy and third-wave-mindfulness-based therapies for patients suffering from depression measured using the Beck-Depression-Inventory (BDI): A systematic literature review and network-meta-analysis.
Journal of affective disorders – March 05, 2025
Summary
Mindfulness-based therapies, part of the "third wave" of cognitive behavioral therapy, show promise in treating depression. A systematic review and meta-analysis revealed that both mindfulness and traditional CBT significantly improve depression outcomes. While mindfulness had a slight edge, both approaches effectively support recovery, highlighting their value in mental health treatment.
Abstract
Mindfulness-based therapies (MBT) are proposed as a "third wave" of cognitive-behavioral therapy (CBT). This network meta-analysis investigated thi...
Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans
bioRxiv – March 03, 2025
Summary
Psychedelics may have unique effects beyond serotonin pathways. In a study using the tiny worm C. elegans, exposure to 2,5-dimethoxy-4-iodoamphetamine (DOI) inhibited feeding but did not alter movement or egg-laying. This suggests new avenues for understanding psychedelics and their potential in treating mental health issues.
Abstract
ABSTRACT: Psychedelics show promise in treating depression, PTSD, and substance use disorder, prompting research into their mechanisms of action. M...
Self-Deprivation: A Proposal for a Maladaptive Behavioral Outcome for Survivors of Childhood Maltreatment.
Journal of child & adolescent trauma – March 01, 2025
Summary
Childhood maltreatment can lead to surprising self-harming behaviors, such as neglecting self-care. A study of 120 adults revealed that those with a history of abuse often engaged in self-deprivation—intentionally avoiding self-care as a form of harm. This insight highlights the complex ways trauma impacts well-being and underscores the importance of understanding these behaviors for better support and healing.
Abstract
Childhood maltreatment is associated with significant psychological distress and coping-related maladaptive behaviors that can extend into adulthoo...
Is dosage of a meditation app associated with changes in psychological distress? It depends on how you ask.
Clinical psychological science : a journal of the Association for Psychological Science – March 01, 2025
Summary
Engaging with a meditation app can lead to significant reductions in psychological distress, but the relationship isn't straightforward. By analyzing various usage metrics, researchers found that higher dosage often correlates with improved outcomes. This highlights the need for optimization in mobile health interventions to maximize benefits.
Abstract
Despite growing popularity, associations between dosage and outcomes in meditation app interventions have not been established. We examined this re...
The Selective 5HT2A Receptor Agonist, 25CN-NBOH Exerts Excitatory and Inhibitory Cellular Actions on Mouse Medial Prefrontal Cortical Neurons.
Synapse (New York, N.Y.) – March 01, 2025
Summary
Recent findings reveal that a synthetic psychedelic, known for its strong connection to serotonin receptors, can both excite and inhibit brain activity. In mouse brain slices, researchers recorded action potentials showing that while higher doses increased excitatory signals, they also suppressed neuron firing. This dual effect enhances our understanding of psychedelics' therapeutic potential.
Abstract
Psychedelic compounds have gained renewed interest due to their rapid and long-lasting therapeutic effects on stress-related disorders. While the u...
Psychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy.
Cancer medicine – March 01, 2025
Summary
Psychedelics like LSD and psilocybin show promise in alleviating cancer pain and the psychological distress that often accompanies it. With high rates of anxiety and depression among cancer patients, these substances may offer a novel approach to treatment. Early studies indicate positive results, suggesting a potential breakthrough in managing cancer-related distress effectively.
Abstract
To evaluate the current level of evidence for the use of psychedelics for the management of cancer pain and associated psychological distress. Pain...
Role of Meditation as Adjuvant Therapy on Gastrointestinal Quality of Life among Individuals with Functional Dyspepsia in an Outpatient Setting: A Randomized Pilot Trial.
The Journal of the Association of Physicians of India – March 01, 2025
Summary
Meditation may be a game-changer for those suffering from functional dyspepsia, a common gastrointestinal issue. A recent study found that adding meditation to standard treatments significantly improved patients' quality of life, mental health, and sleep quality. This holistic approach could enhance overall well-being while minimizing medication side effects.
Abstract
Functional dyspepsia (FD) is one of the most common reasons for medical visits. Patients with FD incur large direct and indirect expenditures and m...
Differences in the clinical presentation of acute 3,4-methylenedioxymetamfetamine intoxication by co-intoxication and patient sex to European emergency departments.
Clinical toxicology (Philadelphia, Pa.) – March 01, 2025
Summary
Acute intoxication with 3,4-methylenedioxymetamfetamine (MDMA) can vary significantly based on co-intoxication and patient sex. Analyzing data from the Euro-Den Plus database, researchers found that polydrug use, especially with ethanol, led to more severe symptoms like agitation and psychosis. Notably, females experienced different symptoms than males, highlighting the need for tailored emergency treatments.
Abstract
This study hypothesized that 3,4-methylenedioxymetamfetamine intoxication presents with distinct clinical features and outcomes when combined with ...
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes.
Journal of visualized experiments : JoVE – February 28, 2025
Summary
As cannabinoid use rises, understanding its effects on fetal development is crucial. This study examines how prenatal exposure to delta-9-tetrahydrocannabinol (THC) influences neurodevelopment. Using a preclinical model, researchers found that moderate THC consumption during pregnancy could lead to significant behavioral and cognitive changes in offspring, highlighting the importance of awareness regarding prenatal cannabinoid exposure.
Abstract
Prenatal cannabinoid exposure (PCE) is becoming increasingly frequent as more states across the United States legalize recreational marijuana (cann...
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Impact of Physiological and Psychological Stress on Glaucoma Development and Progression: A Narrative Review.
Medicina (Kaunas, Lithuania) – February 27, 2025
Summary
Glaucoma, a major cause of blindness, is influenced by both physiological and psychological stress. Increased acute and chronic stress can elevate intraocular pressure (IOP), worsening conditions like primary open-angle and angle-closure glaucoma. Mindfulness practices may lower IOP and enhance mental health, improving quality of life for patients. Addressing socioeconomic and environmental stressors could further aid in better outcomes.
Abstract
Glaucoma is a leading cause of irreversible blindness worldwide. Presently, elevated intraocular pressure (IOP) is the only approved modifiable ris...
Ketamine-Assisted Psychotherapy for Generalized Anxiety Disorder: A Comprehensive Case Report with Integrated Neurophysiological Imaging Using Magnetoencephalography
medRxiv – February 25, 2025
Summary
Ketamine-assisted psychotherapy shows promise for treating Generalized Anxiety Disorder. A detailed case study of a male patient revealed significant improvements in anxiety and mood after KAP sessions, supported by neuroimaging that highlighted enhanced brain connectivity. These findings suggest a powerful link between therapy and brain function, paving the way for innovative treatment approaches.
Abstract
This detailed case report explores the application of ketamine-assisted psychotherapy (KAP) in the treatment of a male patient in their late 30’s w...
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Exploring Pain Researcher and Clinician Perceptions of Complementary, Alternative, and Integrative Medicine: A Large-Scale, International Cross-Sectional Survey
medRxiv – February 23, 2025
Summary
A significant number of pain specialists recognize the value of complementary, alternative, and integrative medicine (CAIM) in enhancing patient care. Through a large-scale international survey, researchers found that many clinicians support CAIM approaches, believing they can effectively complement traditional pain management methods.
Abstract
Background Complementary, alternative, and integrative medicine (CAIM) is gaining popularity among patients experiencing pain, alongside traditiona...
Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [125I]Radioiodinated DYRK1A Inhibitor.
Molecules (Basel, Switzerland) – February 21, 2025
Summary
DYRK1A, linked to Tau hyperphosphorylation in Alzheimer's disease and down syndrome, shows promise as a target for imaging. Researchers identified [125I]KuFal184 as a potential imaging agent, demonstrating its selectivity for Tau in brain slices. This advancement could lead to earlier detection of Tauopathies through autoradiography.
Abstract
Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system an...
Psychedelics and Suicide-Related Outcomes: A Systematic Review.
Journal of clinical medicine – February 20, 2025
Summary
Suicide is a leading cause of death globally, emphasizing the urgent need for effective treatments. Recent findings suggest that psychedelics like psilocybin and MDMA may significantly reduce suicidal thoughts in individuals with mood and psychiatric disorders. Studies indicate notable improvements in suicidal ideation, showcasing the potential of these therapies for enhancing mental health outcomes.
Abstract
Background/Objectives: Suicide accounts for 1.4% of global deaths, and the slow-acting nature of traditional treatments for suicide risk underscore...
Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids.
Biomolecules – February 20, 2025
Summary
Long-term meditation may significantly lower stress and aging markers. In a study comparing practitioners to non-meditators, those who practiced Transcendental Meditation showed improved cognitive function and reduced cortisol levels, indicating lower allostatic load. These findings highlight meditation's potential for public health and stress reduction.
Abstract
Background: Our previous comparison of peripheral blood mononuclear cells (PBMCs) from long-term Transcendental Meditation® (TM®) practitioners and...
Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder
medRxiv – February 18, 2025
Summary
Recent changes in Australia now allow MDMA to be prescribed for PTSD, marking a significant shift in therapeutic approaches. A new clinical guideline outlines how this treatment can be effectively integrated into psychotherapy. The findings highlight MDMA's potential to enhance emotional processing and improve patient outcomes, offering hope for those affected by trauma.
Abstract
Introduction Despite recent clinical and research interest, medical use of psychedelics has not been legalised in most jurisdictions. The Australia...
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DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance
bioRxiv – February 17, 2025
Summary
Starvation resistance is crucial for survival and health. Research reveals that DAF-18, a C. elegans version of the tumor suppressor PTEN, enhances this resistance by protecting LIN-35/Rb from harmful cleavage. This interaction aids in repressing certain genes, showcasing a vital link between tumor suppressors and survival mechanisms.
Abstract
Starvation resistance is a fundamental trait with profound influence on fitness and disease risk. DAF-18, the C. elegans ortholog of the tumor supp...
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Boosting reliability when inferring interactions from time series data in gene regulatory networks
bioRxiv – February 17, 2025
Summary
Imagine unlocking the secrets of gene interactions with greater accuracy! By refining an existing algorithm, researchers have enhanced the reliability of predicting how genes regulate each other over time. Using innovative methods and simulated data, they achieved impressive improvements in prediction performance, showcasing the power of incorporating prior knowledge into gene studies.
Abstract
In the context of the dynGENIE3 [13] approach for inferring regulatory network interactions from time-series data, we show that it is possible to m...
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PyOrthoANI, PyFastANI, and Pyskani: a suite of Python libraries for computation of average nucleotide identity
bioRxiv – February 13, 2025
Summary
Average nucleotide identity (ANI) is essential for identifying prokaryotic species in genomics. New Python libraries—PyOrthoANI, PyFastANI, and Pyskani—simplify ANI calculations, producing results consistent with established methods. They integrate smoothly with BioPython, enhancing bioinformatic workflows and making genomic analysis more accessible.
Abstract
Summary The average nucleotide identity (ANI) metric has become the gold standard for prokaryotic species delineation in the genomics era. The most...
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Passive sensing with psyche: utilizing data from wearable technology to predict emotion states
medRxiv – February 13, 2025
Summary
Imagine if your smartwatch could help you understand your emotions better. This study reveals how wearable technology, like FitBits, can predict daily mood states—such as happiness or anxiety—using data from 38 participants over nearly 1,200 days. By employing advanced machine learning, researchers demonstrated that monitoring physiological signals can enhance emotional awareness and support timely interventions for mental health.
Abstract
Depression and anxiety are some of the most common mental health disorders in the world contributing to significant morbidity and mortality. Past t...
Phenethylaminylation: Preliminary In Vitro Evidence for the Covalent Transamidation of Psychedelic Phenethylamines to Glial Proteins using 3,5-Dimethoxy-4-(2-Propynyloxy)-Phenethylamine as a Model Compound
bioRxiv – February 13, 2025
Summary
Psychedelics may reshape our brains in lasting ways beyond their immediate effects. This study explores how these substances could chemically modify glial proteins, potentially influencing long-term cognitive changes. Using a modified mescaline, researchers discovered that various glial proteins might be altered, opening exciting avenues for understanding psychedelics' therapeutic potential.
Abstract
Psychedelics are well known for their ability to produce profoundly altered states of consciousness. But, more importantly, the effects of psychede...
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Juggling the Limits of Lucidity: Searching for Cognitive Constraints in Dream Motor Practice
bioRxiv – February 12, 2025
Summary
Lucid dreaming opens doors to unique experiences, including practicing complex skills like juggling. In a study with eight participants, two successfully juggled in their dreams, showcasing high dream control. This highlights how traits like motivation and self-efficacy influence the ability to steer dreams, paving the way for exciting applications in therapy and training.
Abstract
Lucid dreaming (LD), during which the dreamer becomes aware of the dream state, offers a unique opportunity for a variety of applications, includin...
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EEG Microstates reveal distinct network dynamics in lucid and non-lucid REM sleep
bioRxiv – February 12, 2025
Summary
Lucid dreaming, where one is aware they're dreaming, showcases unique brain activity. Analyzing sleep recordings from lucid dreamers revealed that specific brain microstates dominate during lucid REM sleep, enhancing self-awareness and cognitive functions. In contrast, non-lucid dreams engage different networks, suggesting distinct mental processes at play.
Abstract
During lucid dreaming, the dreamer is aware that they are dreaming. In past years, numerous studies have explored the characteristics of lucid drea...