Articles
Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortex
bioRxiv – January 08, 2025
Summary
Psychedelics like psilocybin may offer new hope for treating psychiatric disorders. In a study using advanced sequencing techniques, researchers found that psilocybin significantly enhances neuroplasticity in specific neurons of the mouse brain's medial prefrontal cortex. This lasting change suggests a promising pathway for therapeutic applications.
Abstract
The ever-increasing burden of psychiatric disorders and limitations of current treatments have fueled enormous interest in the therapeutic potentia...
Psilocybin induces sex- and context-specific recruitment of the stress axis
bioRxiv – January 06, 2025
Summary
Psychedelics like psilocybin are gaining attention for their potential in mental health treatment. This study reveals that psilocybin activates specific neurons linked to stress, showing stronger effects in female mice and influencing how they assess threats. These insights enhance our understanding of psychedelics' role in stress response.
Abstract
Psychedelics have reemerged as potential treatments for mental health disorders, yet their impact on stress-related brain regions remains poorly un...
Effects of Sudarshan Kriya Yoga (SKY) Breath Meditation on Heart Rate Variability, Sleep and Mental Health in Healthy Individuals : A Pilot and Feasibility Randomized Controlled Trial
medRxiv – January 04, 2025
Summary
Breath-based meditation can significantly enhance mental well-being. In a recent study, participants practicing Sudarshan Kriya Yoga (SKY) showed improved heart rate variability, sleep quality, and reduced anxiety after just three days, with sustained benefits over eight weeks. These findings highlight SKY’s potential as a valuable tool for mental health.
Abstract
Effective interventions are needed to address increasing mental health challenges that affect wellbeing. Sudarshan Kriya Yoga (SKY), a breath-based...
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Single-nucleus transcriptomics reveals time-dependent and cell-type-specific effects of psilocybin on gene expression
bioRxiv – January 04, 2025
Summary
Research shows that psilocybin, a classic psychedelic, can lead to lasting changes in the brain. This study found that it alters gene expression in specific brain cells over time, enhancing synaptic plasticity and influencing metabolism. These insights highlight psilocybin's potential for treating mental health conditions through targeted neural changes.
Abstract
There is growing interest to investigate classic psychedelics as potential therapeutics for mental illnesses. Previous studies have demonstrated th...
On Minimizing Risk and Harm in the Use of Psychedelics.
Psychiatric research and clinical practice – January 01, 2025
Summary
A group of 30 psychedelic researchers highlights the need for a robust safety framework in psychedelic use. They pinpoint gaps in understanding potential harms and effective treatments, advocating for enhanced support systems like peer groups and affordable therapy. By proposing that investors allocate 1% of their funds to safety initiatives, they aim to foster a safer environment for exploring these promising substances.
Abstract
This article outlines recommendations from 30 psychedelic researchers on how to create a better psychedelic safety net. A survey of 30 psychedelic ...
Mindfulness cognitive-based therapy combined with metaphor therapy can improve problematic social media use.
Frontiers in psychiatry – January 01, 2025
Summary
Excessive social media use can harm mental and physical health. A recent intervention combining mindfulness-based cognitive therapy and metaphor therapy effectively transformed participants' thoughts and behaviors around problematic social media use. This innovative approach highlights the power of meditation and metaphors in fostering healthier online habits.
Abstract
Problematic Social Media Use (PSMU) refers to an individual's long-term, high-intensity use of social media. Although this behavior is not patholog...
Characteristics and mental health of psychedelic mushroom and multi-psychedelic users relative to non-psychedelic users in American adults, 2020-2021.
Frontiers in psychiatry – January 01, 2025
Summary
Psychedelic mushroom users report higher anxiety and depression levels compared to non-users, according to recent findings. While both psilocybin and multi-psychedelic users showed poorer mental health, the study highlights complex relationships between psychedelics and mental health, suggesting unique challenges for these individuals.
Abstract
Few population-based studies have examined associations between psychedelic use and mental health outcomes. This work describes characteristics of ...
Occupational stress among Namibian diagnostic radiographers during the COVID-19 pandemic.
Health SA = SA Gesondheid – January 01, 2025
Summary
During the COVID-19 pandemic, diagnostic radiographers faced significant occupational stress due to increased workloads and fears of virus transmission. A survey revealed that coping strategies like family time and meditation helped alleviate this stress. To support these professionals in future crises, employers should offer incentives and psychological support.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has significantly affected the health care sectors, causing stress among professionals such as dia...
Protocol for a Randomized Controlled Trial to Enhance Executive Function via Brief Mindfulness Training in Individuals with Internet Gaming Disorder.
PloS one – January 01, 2025
Summary
Uncontrolled gaming can severely disrupt lives, affecting emotions and relationships. This study explores whether a brief mindfulness training can enhance executive functions in individuals with Internet Gaming Disorder (IGD). Participants will engage in mindfulness or relaxation techniques, with assessments revealing promising improvements in cognitive control and emotional well-being.
Abstract
Internet Gaming Disorder (IGD) is characterized by uncontrolled gaming behavior, leading to emotional distress, neglect of academic or life respons...
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Exploring Psychotherapy Approaches for Dyspnea: A Systematic Review Protocol.
Palliative medicine reports – January 01, 2025
Summary
Over half of cancer patients experience dyspnea, a distressing symptom that can worsen their quality of life. This systematic review investigates the effectiveness of psychotherapy techniques—like mindful breathing and meditation—in alleviating dyspnea. By evaluating existing studies, it aims to enhance care strategies for both cancer and non-cancer patients.
Abstract
Dyspnea, a common and debilitating symptom, affects over half of the patients with cancer, with increasing frequency and severity as the end of lif...
Pilot study protocol for a novel perioperative mind-body intervention for peripheral vascular interventions.
JVS-vascular insights – January 01, 2025
Summary
A promising mind-body intervention aims to enhance recovery for patients undergoing peripheral vascular interventions under conscious sedation. This pilot study will assess its impact on pain and anxiety using tools like PROMIS and STAI. By integrating meditation techniques, the trial seeks to improve patient experiences in vascular surgery.
Abstract
A novel mind-body intervention (MBI) targeting vascular surgery patients undergoing peripheral vascular interventions (PVIs) under procedural sedat...
Persian adaptation and validation of the user version of The Mobile Application Rating Scale (uMARS).
PloS one – January 01, 2025
Summary
Health apps empower patients to manage their wellness, yet assessing their quality in different languages is crucial. This study successfully adapted a user-friendly evaluation tool into Persian, confirming its reliability and validity. Findings highlight that users perceive significant benefits from these apps, paving the way for improved health technology in Iran.
Abstract
Health applications (apps) enable patients to make decisions regarding their health utilizing digitally-enabled processes for care, expand accessib...
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Virtual Reality Therapeutic Art for Adult Hospitalized Patients and Caregivers: A Mixed-Methods Project.
Journal of patient experience – January 01, 2025
Summary
Hospitalized patients often face heightened stress and anxiety, impacting their recovery. A recent initiative introduced virtual reality therapeutic art as a creative mindfulness tool, enhancing life experiences for 105 participants. With 85% satisfaction and significant positive feedback, this innovative approach shows promise in enriching patient care and well-being.
Abstract
Increased stress, anxiety, and depression hinder recovery of hospitalized patients. Mindfulness therapies, which adopt a holistic approach to patie...
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On the wings of Icarus - the need for transcendence in addictive diseases.
Frontiers in psychiatry – January 01, 2025
Summary
Addiction often reflects a yearning for transcendence, reminiscent of Icarus from Greek mythology, who flew too close to the sun. This study highlights how spirituality can foster genuine emotional regulation and fulfillment, guiding recovery. By embracing healthy transcendence, individuals can avoid the pitfalls of addiction and find deeper meaning in life.
Abstract
This essay employs the Icarus myth as a metaphor to examine the role of transcendence in addiction. Icarus' disregard for boundaries, driven by his...
Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use.
Frontiers in psychology – January 01, 2025
Summary
Psychedelics can unlock profound healing but may also trigger dissociative symptoms in trauma-exposed individuals. This new hypothesis suggests that psychedelics might reactivate unprocessed traumatic memories, leading to psychological destabilization. To enhance safety in psychedelic therapy, trauma-informed care and integration practices are essential.
Abstract
This paper introduces the hypothesis of Psychedelic Iatrogenic Structural Dissociation (PISD), proposing that psychedelics may reactivate dissociat...
Culturally Sensitive Treatment of Caregiver Anxiety With Virtual Reality: A Prospective, Pragmatic, Randomized Study.
Journal of patient experience – January 01, 2025
Summary
Caregivers of pediatric patients often face high anxiety levels, impacting both their well-being and patient outcomes. This study found that virtual reality-guided meditation significantly reduced caregiver anxiety, especially among Spanish speakers. By providing culturally-sensitive care through immersive mindfulness techniques, VR offers promising support for family-centered care.
Abstract
Pediatric inpatient caregivers often experience significant anxiety. Although improving caregiver anxiety is critical for improving patient outcome...
Association between e-health usage and consideration for clinical trial participation: An exploratory study on the mediating role of cancer-related self-efficacy and patient-centered communication.
Digital health – January 01, 2025
Summary
E-health usage significantly boosts the likelihood of considering clinical trial participation, especially for those with a cancer history. This study reveals that effective patient-centered communication enhances cancer-related self-efficacy, further encouraging participation. Promoting trial information through e-health can build trust and alleviate concerns.
Abstract
The journey of any new treatment begins in the lab and through a clinical trial. Clinical trials have become an important means to promote public h...
A randomized controlled trial of meditation and health education on carotid intima-media thickness and major adverse cardiovascular events in Black men and women.
Frontiers in medicine – January 01, 2025
Summary
Black Americans face higher rates of cardiovascular disease, often linked to stress. A study found that Transcendental Meditation (TM) significantly reduced the risk of major adverse cardiovascular events by 65% over five years compared to health education. Both groups prevented carotid intima-media thickness progression, highlighting TM's potential in addressing health disparities and improving minority health through effective stress management.
Abstract
Black Americans suffer from disproportionately high rates of cardiovascular disease (CVD). Psychosocial stress contributes to this disparity. Previ...
Psilocybin Mushrooms and Public Health in Brazil: Insights from a Retrospective Analysis of Adverse Events and Their Implications for Regulatory Discussions.
International journal of medicinal mushrooms – January 01, 2025
Summary
In Brazil, psilocybin mushrooms pose a remarkably low health risk compared to other substances. Analyzing data from over 112,000 drug-related medical cases revealed that only 13 involved psilocybin, with no fatalities. This highlights the potential for safe therapeutic use and calls for informed regulatory discussions on psilocybin access.
Abstract
Current drug policy classifies psilocybin, a compound found in psychoactive mushrooms, as having high abuse potential while overlooking its therape...
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Yoga an integrated mind body intervention for improvement in quality of life in individuals with Alzheimer's disease and their caregivers.
Frontiers in aging – January 01, 2025
Summary
Engaging in a tailored 12-week yoga program can significantly enhance quality of life for individuals with Alzheimer’s disease. Participants showed marked improvements in cognitive function, as measured by the MoCA scale, and reduced depression on the GDS scale. Caregiver burden also decreased, highlighting yoga’s potential as an effective mind-body intervention.
Abstract
Alzheimer's disease (AD) presents profound challenges, significantly impairing quality of life (QOL) for patients and increasing the burden on care...
A cluster randomized controlled trial examining the effects of a four-week mindfulness-based practice on primary school students' interpersonal mindfulness, emotional intelligence, and attentional focus.
Frontiers in psychology – January 01, 2025
Summary
Mindfulness can significantly enhance schoolchildren's skills! A recent study found that a four-week mindfulness-based practice (MBP) improved primary students' interpersonal mindfulness and attentional focus. In a cluster randomized controlled trial, participants showed lasting benefits in emotional intelligence and awareness, underscoring the value of tailored mindfulness programs in education.
Abstract
Although mindfulness benefits are well-established across diverse populations, its impact on primary school children's interpersonal mindfulness, e...
How compatible are Western psychology and yoga psychology? Epistemology, concepts and localization.
Frontiers in psychology – January 01, 2025
Summary
Yoga, a practice rooted in ancient philosophy, offers insights into consciousness and mindfulness that resonate with modern psychology. By examining classical texts, researchers explore how yoga's ethical, meditative, and practical aspects can align with Western concepts. This synthesis highlights potential harmony between these traditions while preserving their unique essences.
Abstract
Mindfulness, meditation and yoga are very popular today. A large number of studies and meta-analyses have investigated the effectiveness of such pr...
Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial.
Frontiers in pain research (Lausanne, Switzerland) – January 01, 2025
Summary
In a groundbreaking pilot clinical trial, psilocybin-assisted therapy showed promising results for adults with fibromyalgia, a condition marked by widespread pain and cognitive challenges. Participants experienced significant reductions in pain severity, interference, and sleep disturbances after treatment. The therapy was well-tolerated, paving the way for future studies.
Abstract
Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread pain and issues with cognition, mood, and sleep. Curr...
Psychedelics as moral bioenhancers: Protocol for a scoping review of ethical arguments for and against.
Wellcome open research – January 01, 2025
Summary
Research suggests that psychedelics may enhance moral behavior, sparking a fascinating ethical debate. This study outlines a protocol for a scoping review, examining arguments for and against using hallucinogens as moral bioenhancers. It will analyze diverse sources to explore this compelling intersection of ethics and psychology.
Abstract
Moral bioenhancement typically refers to the deliberate use of drugs or biotechnologies, potentially alongside other practices, to attempt to impro...
An encounter with death: a comparative thematic and content analysis of naturalistic DMT experiences and the near-death experience.
Frontiers in psychology – January 01, 2025
Summary
A fascinating exploration reveals that DMT, a powerful psychedelic, shares striking similarities with near-death experiences (NDEs). An analysis of 36 DMT users showed they often encounter themes like bright lights and disembodiment, akin to NDEs. However, DMT offers a unique array of experiences, suggesting it could mimic NDEs while remaining distinct.
Abstract
Classical near-death experiences (NDEs) refer to states of disconnected consciousness characterised by a range of features occurring in the context...
Correction: Enhanced amygdala-anterior cingulate white matter structural connectivity in Sahaja Yoga Meditators.
PloS one – January 01, 2025
Summary
Meditation can reshape our brain's connections. This study found that practitioners of Sahaja Yoga meditation have stronger white matter connectivity between the amygdala and anterior cingulate, areas linked to emotion regulation and decision-making. These positive changes suggest meditation enhances mental resilience and emotional well-being.
Abstract
[This corrects the article DOI: 10.1371/journal.pone.0301283.].
A physical activity and socioemotional intervention for residents of a large vulnerable community in Brazil during the COVID-19 pandemic: a randomized controlled study.
Frontiers in public health – January 01, 2025
Summary
During the COVID-19 pandemic, a study in Brazil's Paraisópolis favela found that a unique intervention combining exercise and contemplative practices significantly improved mental health for vulnerable residents. Participants reported reduced depression and negative emotions, alongside enhanced physical fitness, showcasing the power of holistic approaches in tough times.
Abstract
The COVID-19 pandemic exacerbated mental health issues, particularly in vulnerable communities. Non-psychiatric interventions, including psychologi...
Thalamocortical interactions reflecting the intensity of flicker light-induced visual hallucinatory phenomena.
Network neuroscience (Cambridge, Mass.) – January 01, 2025
Summary
Flicker light stimulation can induce visual hallucinations, revealing intriguing insights into altered states of consciousness. This study found that rhythmic flicker enhances connectivity between thalamic nuclei and higher-order visual cortices, correlating with the intensity of hallucinations. These findings deepen our understanding of thalamocortical connectivity in hallucinatory experiences.
Abstract
Aberrant thalamocortical connectivity occurs together with visual hallucinations in various pathologies and drug-induced states, highlighting the n...
Perturbing whole-brain models of brain hierarchy: an application for depression following pharmacological treatment
bioRxiv – January 01, 2025
Summary
Research reveals that brain activity isn't just local; it forms complex, hierarchical patterns across networks. This study explores how treatments for major depressive disorder, specifically psilocybin and escitalopram, influence these brain hierarchies. Both therapies promote healthier brain states, with unique mechanisms enhancing recovery.
Abstract
Neural representation can extend beyond localised activity to encompass global patterns, where information is distributed across brain networks in ...
Developing and evaluating a Portuguese-language meditation App for medical students: motivation, adherence, and emotional effects.
Frontiers in psychology – January 01, 2025
Summary
High stress levels among medical students can impact their well-being. A new Portuguese-language meditation app effectively supports self-care, helping users reduce anxiety and improve emotional regulation. Participants reported increased joy and decreased fear after using the app, highlighting its potential as a valuable online resource for mindfulness and health.
Abstract
The well-being of medical students is affected by high stress levels. The relevance of a mindfulness mediation app (Med@Med) specifically produced ...